Plasma cell disorders like multiple myeloma, plasmacytoma, smoldering myeloma, MGUS are diseases in which the body makes too many plasma cells. These disorders have different symptoms, treatments, and prognoses. The myeloma panel is talking to Dr. Craig Hofmeister from Winship Cancer Institute on advances in treatments for early stage plasma cell disorders. The discussion would cover smoldering myeloma, focusing on updates from ECOG trial discussed at ASCO2019, treatments of newly diagnosed myeloma based on the results of CASSIOPEIA trial and use of precision medicine to treat patients in the first relapse, highlighting MYDRUG trial.