Over 10 million people in the US have a neurodegenerative condition. Half of these people have Alzheimer's Disease making it the most common neurodegenerative condition in the US. Among the remaining, a large population suffer from frontotemporal dementia (FTD). However, FTD and Alzheimer's are very often misdiagnosed for each other and even the terms are used interchangeably. In reality, they are two different diseases that have varying effects on behavior. It is important to differentiate between the two so that patients and families can know what to expect and receive targeted therapies. We discussed FTD and Alzheimer's Disease, their similarities, differences, risk, diagnostic tests, progression stages, treatments and clinical trials with Dr. Murray Grossman and Dr. David Wolk from the University of Pennsylvania.