Guided Search for Finding Matching Parkinson’s Clinical Trials: Explore 5 Promising Studies Advancing Care
Every April, Parkinson’s Awareness Month draws attention to one of the world’s fastest-growing neurological conditions. Parkinson’s disease is a progressive disorder leading to tremors, stiffness, slowed movement, and cognitive changes affecting more than 10 million people globally — a number projected to reach 20–25 million by 2050.
While treatments are available to help manage symptoms, no approved therapy currently slows or stops disease progression — making ongoing research and clinical trial participation essential for advancing care.
Since 2000, the Michael J. Fox Foundation has supported research funding, helped develop new diagnostic tools, and encouraged trial participation. As part of this effort, we at TrialX are proud to support the Michael J. Fox Foundation through our AI-powered global clinical trial finder—helping connect patients and caregivers to relevant Parkinson’s research studies.
“Parkinson’s patients are the experts on what we have. We have a responsibility as patients to share our experience — what works for us, what we respond to, what we can contribute to research.”— Michael J. Fox
Making Clinical Trial Discovery Simpler for the Parkinson’s Community with Fox Trial Finder
The Fox Trial Finder, powered by TrialX, is designed to make clinical trial information easier to navigate. It offers two ways to get started and is available in seven languages, including English, French, Spanish, Hindi, Korean, Chinese, and Russian.
Guided Search: A step-by-step way to find relevant trials
The guided search option is ideal for individuals who are new to clinical research or prefer a step-by-step guided experience.
It begins with simple, easy-to-understand information about clinical trials and what participation may involve, along with access to a clinical trial primer explaining potential risks and benefits.
Users are then asked a few key questions, such as:
- Location
- Age
- Diagnosis details
- Willingness to travel
Based on these inputs, the platform presents clinical trials that may be relevant. This step-by-step approach simplifies the process and offers a clear starting point for those considering research participation.
Search on your own: Browse available studies
For those who prefer to explore independently, the trial finder also offers a self-directed search option.
Users can browse Parkinson’s studies and apply filters such as:
- Location
- Trial phase
- Study type
- Remote or online participation options
- Languages at the study center
- Keywords
This allows users to review and compare studies at their own pace and focus on areas that are most relevant to them.
Contact options are also included, making it easier to reach out to study teams for more information.
A Few Ongoing Parkinson’s Clinical Trials Currently Recruiting Participants
- Dual Frequency, Dual Region Deep Brain Stimulation
Sponsor: University of California, Davis
This interventional study is exploring a new approach to deep-brain stimulation (DBS) in people with Parkinson’s disease. While standard DBS is effective in managing motor symptoms, it may sometimes affect cognitive functions such as verbal fluency and decision-making. This study aims to evaluate whether combining low-frequency stimulation in one region of the brain with standard high-frequency stimulation in another can help improve cognitive outcomes while maintaining motor benefits.
Researchers will assess changes in cognition, mood, impulsivity, and motor function over time to better understand the safety, tolerability, and effectiveness of this dual stimulation approach. The findings may help refine DBS therapy and improve the quality of life for people living with Parkinson’s disease.
Locations: Recruiting at UC Davis Health in Sacramento, California, United States.
Learn more about the study and see if you may be eligible to participate.
- PPMI Clinical Study in Parkinson’s Disease
Sponsor: Michael J. Fox Foundation for Parkinson’s Research
This large, global observational study is designed to better understand how Parkinson’s disease progresses over time. Researchers are following people with Parkinson’s disease, those at risk of developing it, individuals with genetic variants linked to Parkinson’s, and healthy volunteers to track changes in symptoms and underlying biology. The study will collect a wide range of data, including clinical assessments, imaging, digital health data, and biological and genetic samples. The goal is to identify reliable markers of disease progression that can help improve the design of future clinical trials and support the development of therapies that slow or prevent disease progression.
Locations: Recruiting at multiple sites worldwide, including across the United States, Canada, Europe, and other international locations.
Learn more about the study and see if you may be eligible to participate.
- Bemdaneprocel Study in Parkinson’s Disease (exPDite-2)
Sponsor: BlueRock Therapeutics
This Phase 3 clinical trial is evaluating the safety and effectiveness of bemdaneprocel, an investigational cell therapy designed to replace dopamine-producing neurons in people with Parkinson’s disease. The goal is to improve motor symptoms and overall quality of life. Participants will be randomly assigned to receive either the cell therapy or a placebo surgical procedure, allowing researchers to compare outcomes between groups. The study will assess changes in motor function, daily symptom control, non-motor symptoms, and medication use over time, with follow-up lasting several years.
Locations: Recruiting at multiple sites across the United States, Canada, and Australia, including California, Texas, New York, Ontario, British Columbia, and others.
Learn more about the study and see if you may be eligible to participate.
- Personalized Stem Cell Transplant Study
Sponsor: Massachusetts General Hospital
This Phase 1 clinical trial is evaluating the safety and feasibility of a personalized cell therapy approach for people with Parkinson’s disease. The treatment uses a patient’s own skin cells to create dopamine-producing neurons, which are then transplanted into the brain. The goal is to restore lost dopamine function and improve symptoms. This early-stage study is focused primarily on safety and how well the procedure is tolerated. Researchers will also explore potential improvements in motor function, symptom control, and quality of life using clinical assessments and brain imaging over a two-year period.
Location: Recruiting at a single site in Boston.
Learn more about the study and see if you may be eligible to participate.
- Intranasal Insulin and Glutathione Study in Parkinson’s Disease (NOSE-PD)
Sponsor: Gateway Institute for Brain Research
This Phase 2 clinical trial is evaluating the safety and effectiveness of intranasal insulin and glutathione as an add-on therapy for people with Parkinson’s disease. The goal is to explore whether this combination can help improve motor and cognitive symptoms when used alongside standard treatments. Participants are randomly assigned to receive either the active treatment or a placebo, administered through a nasal spray. This allows researchers to compare outcomes between the two groups in a controlled setting. The study will assess changes in motor function, thinking and memory (cognitive function), mood, and overall quality of life over several months, along with monitoring safety and tolerability.
Locations: Recruiting at two sites in Florida.
Learn more about the study and see if you may be eligible to participate.
Explore Ongoing Parkinson’s Clinical Trials
World Parkinson’s Day highlights the importance of awareness and participation in research. Increasing access to clinical trial information helps move the field forward and supports progress for the entire Parkinson’s community.
If you or someone you care for is living with Parkinson’s and would like to learn more about ongoing studies, the Fox Trial Finder provides a starting point for exploring current research opportunities. You can also consider joining the volunteer registry to stay informed about future studies.
