COVID-19 Clinical Trial Recruitment supported through iConnect
TrialX assists academic medical centers in recruitment for clinical research by offering iConnect, a patient friendly, centralized trial listing and recruitment platform. We proudly support research recruitment at Penn Medicine, Indiana CTSI, NYU and BIDMC.
Below is a list of COVID-19 trials currently being conducted. This list will be updated frequently to reflect new studies.
Last updated: June 4, 2020
Summary: HVTN 405/HPTN 1901 will describe immune responses in study participants with a history of recovering from SARS- CoV-2 infection. A main aim of HVTN 405/HPTN 1901 is to develop antibody assays that can be reliably used to detect SARS-CoV-2 infection in vaccine and monoclonal antibody studies to prevent COVID-19. This information will be critical in illuminating the path to the development and testing of safe and effective vaccine and antibody interventions to prevent COVID-19.
Summary: The overall purpose of the biobank is to collect and store biological specimens, such as blood, urine, respiratory specimens, other bodily fluids, and tissue where available, as well as health information. Storing these samples and this information allows researchers to use them for research studies, including but not limited to COVID-19.
Summary: This study will examine whether quinine topical nasal spray administered for 4 weeks is safe, tolerated, and can reduce the incidence of confirmed SARS-CoV-2 (also known as COVID-19) in health care professionals.
Summary: We plan to perform a prospective cohort study to study the fit factor of a modified surgical mask compared to that of a N95 mask and the unmodified standard surgical mask. In the process, we will also quantitatively characterize differences between masks.
Summary: The purpose of the survey is to better understand the stresses of confinement and the strategies people are using to cope with confinement. You can contribute to that understanding by participating in this COVID-19 Confinement Survey.
Summary: The purpose of this study is to develop a possible new treatment for COVID-19 disease which uses antibodies against this virus. Antibodies are natural proteins made by the body that attack viruses and other germs. These antibodies are found in plasma, the yellow, clear part of the blood.
Summary: The main purpose of this research is to determine whether mesenchymal stromal stem cells are effective and safe in helping patients with moderate to severe ARDS due to COVID-19 infection.
Summary: Study is seeking people who have recovered from COVID-19 and are willing to donate blood which will be used in a subsequent convalescent plasma study to transfuse into patients who are critically ill and on mechanical ventilator for COVID-19
Summary: Seeking blood donations from those with confirmed and suspected COVID-19 exposure for biobank storage.
Summary: This trial is investigating use of Remdesivir for treatment of COVID-19 patients currently admitted to hospital. Study is sponsored by Gilead Pharmaceuticals
The PATCH Trials: This trial is investigating use of Hydroxychloroquine, antimalarial treatment that has been widely discussed by American media. This study is split into 2 study groups:
Summary: Phase 1 study investigating safety of vaccine used to prevent COVID-19. Trial is sponsored by Inovio Pharmaceuticals. Penn Medicine is one of only two study sites recruiting for this trial.
Summary: The purpose of this study is to compare the effect of stopping versus continuing ACEI or ARBS in patients who have COVID-19. Patients must currently be admitted to hospital for COVID-19
This study aims to invent a test that can see tiny pieces of infection in a person’s urine (specifically DNA and RNA from a person’s infection). We plan to find material of SARS-CoV-2, the virus causing Covid19.
Summary: We are looking for adults age 18 or older to complete an online questionnaire one per month for the next 12 months. The questionnaire will ask about your health history, your experiences and behaviors, and questions about your diabetes experience, if you have diabetes. Each questionnaire should take about 20 to 30 minutes to complete.
Summary: The Indiana Biobank is looking for volunteers who have recovered from COVID-19 and are willing to donate a blood sample to be used in research to improve testing and develop treatments for COVID-19.
Summary: This study is seeking people and families who live in Marion County, Indiana to take a test for COVID-19. The goal is to determine how many people test positive but are asymptomatic.
Summary: The purpose of this study is to understand if taking hydroxychloroquine (HCQ) may be used to help treat people infected with early SARS-CoV-2 infection.
Summary: The main purpose of this study is to determine if sarilumab is safe and if it can decrease the amount of time someone would have COVID-19 symptoms. Sarilumab (also known as Kevzara®) This study is for hospitalized COVID-19 patients.
Summary: The purpose of this research study is to investigate the safety of treatment with an investigational drug called clazakizumab compared to a placebo in critically ill patients who have been diagnosed with COVID-19 and have signs of respiratory failure.
Summary: The purpose of this study is to investigate the use of hyperbaric oxygen therapy to treat respiratory distress in patients who have tested positive for COVID-19 or have a clear clinical diagnosis of COVID-19 and may require mechanical ventilation.
Summary: The primary objective of this study is to determine whether short-term treatment with colchicine reduces the rate of death and lung complications related to COVID-19.
Summary: By studying the kinetics of the cytokine/immune storm in ARDS COVID patients pre and on ECMO we will be able to (1) describe the baseline time course of specific cytokine elevation and decrease, as well as effects on blood immune genes during ECMO therapy in anticipation of future trials which will involve studying whether in line interventions of cytokine filtration can reduce cytokines responsible for the ARDS.
Summary: The purpose of the study is to compare a lower dose against a higher dose to reduce complications of blood clot formation in patients who are in the hospital due to COVID-19 infection. The drugs used in both regimens, heparin and enoxaparin, are Food and Drug Administration (FDA) approved for preventing clotting events.
Summary: The purpose of the study is to find out if convalescent plasma (the liquid portion of blood of patients who recover from COVID-19) can prevent the development or reduce the severity of respiratory progression in people with COVID-19. This plasma will have substances that could improve the chances of recovery.
Summary: Prospective multicenter registry with an embedded open-label randomized clinical trial to determine the effects of standard of care treatment vs. standard of care plus AT-001 on cardiac structure and function and in-hospital survival in patients hospitalized for management of COVID-19 infection.
Summary: The study will compare the results of the people who receive the study vaccine with those who receive a placebo (a placebo does not contain any active ingredients). Participants will be assigned to one of the groups investigating one of the study vaccines, at one of the vaccine dose levels.
Summary: The purpose of this research study is to see whether remdesivir (RDV) works against SARS-2-CoV.
Summary: The primary objective of this study is to evaluate the efficacy of 2 remdesivir (RDV) regimens compared to standard of care (SOC), with respect to clinical status assessed by a 7-point ordinal scale on Day 11.
Summary: This is a two phase study: Phase 2 study objective is to evaluate the clinical efficacy of sarilumab relative to the control arm in adult patients hospitalized with COVID-19 regardless of severity strata. Phase 3 is evaluating the clinical efficacy of sarilumab relative to the control arm in adult patients hospitalized with COVID-19 (severe and critical).