What Is Fibromyalgia (Symptoms, Cause, Diagnosis, Clinical Trials)?
Fibromyalgia is a musculoskeletal disorder which is accompanied by acute muscular pain, joints pain, frequent mood swings, drastic memory loss, insomnia, and hordes of many other medical and psychological complications. As the name suggests, “fibro” relates to “fibrous”, “myo” , means muscle, and “algia” is scientific synonym to pain. Fibromyalgia is characterized by amplified response to pain and patient tends to develop soft or tender spots in joints and muscles. It is through these tender spots that help doctors perceive the symptoms of the disease. More commonly found in women aged above 45, this condition effects close to 6 million people in the US alone.
Symptoms of Fibromyalgia
Fibromyalgia is a painful condition which drains one out of energy leaving the person fatigued. Host of various complications may occur and these are clustered under the Fibromyalgia Syndrome. Some of the major symptoms of Fibromyalgia syndrome are,
- Acute pain in tender spots
- Severe Headaches often followed by migraine like condition
- Difficulty in bowel movement
- Stiffness in neck and joints
- Tingling sensation in pain area
- Anxiety, Mood swings, heightened irritation
- Numbness in joints
- Softness of tendon and bones
- Bladder anomaly, swallowing problem
- Abnormal eye movement
Fibromyalgia can also be marked by neuropsychiatric conditions. Cognitive impairment and stress on Central nervous system furthers the complication of diseases. Depression and post traumatic abnormalities play major role in triggering the visible symptoms of diseases. Large number of patients complains of facial muscle pain and extreme weakness.
Causes of Fibromyalgia
The definitive cause of fibromyalgia are not known. Despite sometimes unbearable pain, patients barely reflects any inflammatory signs. Scientists believe that an increased level of a neurotransmitter called “Substance P” in the spinal cord fluid and the Central Nervous System creates an heightened sensitive state, which triggers activity of pain receptors. Lowered levels of serotonin, and Ghrelin induces bladder abnormalities, irritable bowel contractions, and dominance of depressive syndromes.
Treatment and Diagnosis of Fibromyalgia
Some of the diagnostic test which help detect the disease include exerting pressure on designated tender points, and eliciting the detailed history of pain. Possible treatments which can be administered individually or in combination are physiotherapy remedies with routine exercise, medications which include antidepressants and pain relievers like Tricycle inhibitors, Selective Serotonin Reuptake Inhibitors, Noradrenaline inhibitors, certain muscle relaxant medicines, and Opioids like tramadol.
Clinical trials of Fibromyalgia
Several clinical trials are being conducted to obtain an in depth knowledge on fibromyalgia. Listed below are some of these Trials.