Post Herpetic Neuralgia (PHN or Herpes Zoster) Clinical Trials, New Treatments

Post Herpetic Neuralgia or PHN is a neuralgic condition, which occurs as an after effect of herpes zoster infection or shingles. In most of the situations, it starts at the time of crusting of herpes zoster vesicles. However, it may also occur after the complete healing of herpes zoster eruption or shingles.

The most common symptom of Post Herpic Neuralgia is continuous pain for 3 months or more. The level of pain can be different at different times, including normal discomfort to severe stabbing pain condition. The area of herpes zoster eruption can also be affected with cutaneous scars. For some patients, it can also be associated with weakness, numbness, tremor or paralysis.

Treatment should be sought whenever a person is detected with shingles or herpes zoster eruption. Early treatment can reduce the chance of Post Herpetic Neuralgia. In case the patient develops Post Herpetic Neuralgia, it may appear sporadically and even after considerable time has elapsed since the initial infection.  Pain controlling medication may be essential for treating Post herpetic Neuralgia, which may include locally applicable topical medicines or oral anti-inflammatory drugs. Antidepressants and anticonvulsants are also used to manage depression and muscle spasms related to PHN. A potential new treatment is XEN402, a topical medication for treating shingles that is being investigated in clinical trials. Recently a vaccine has also been shown to be effective in reducing PHN in elderly patients.

Several new developments are being researched on to invent more effective treatment for Post Herpetic Neuralgia. There are 20 interventions being tested in Post Herpetic Neuralgia clinical trials. These clinical trials are being conducted in 105 cities and are being performed by 23 different clinical trial investigators (doctors who conduct and supervise the clinical study). There are 15 Post Herpetic Neuralgia trials currently active in the United States.

Post Herpetic Neuralgia (Shingles) clinical trials interventions

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Sites/Medical Centers doing Post Herpetic Neuralgia (Shingles) Clinical Trials

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Clinical Trial Investigators for Post Herpetic Neuralgia

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List of Clinical Trials for Post Herpetic Neuralgia

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If you or your friend or family has postherpetic neuralgia, then you may want to find a clinical trial. You can use the Post Herpetic Neuralgia (Shingles) clinical trials tool to find a medical study near you.

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4 thoughts on “Post Herpetic Neuralgia (PHN or Herpes Zoster) Clinical Trials, New Treatments

  1. Thanks very much for the information you provided on this site! I am a high-energy 80 yr old female actor who was ‘downed w/shingles’ following a costume fitting and went to work the next day. By the end of the day I would have preferred death! (Not really, but the next four weeks were the most painful, debilitating days I’ve ever experienced in my life.) The 5th week I slept through. Now, beginning my 6th week, I’m regaining strength and precious energy.

    I’d been ill (flu-like, unexplained fever etc for a couple weeks prior to onset and had finally decided to make an appt w/my physician the next day. Well, instead I awakened w/severe hives which laid the bed for the blisters that would erupt within hours.

    The remains painful supersensity in the areas of my left side affected (neck, back, shoulder, arm and chest) and I’d love to be part of any clinical research programs being done in the Los Angeles area.

    Thanks again for “spelling shingles out” so efficiently.

    Vallean Mann

  2. I have had PHN for 10 months! I have been working with the MAyo Pain Clinic in Phoenix. I am 71 years old! I was considered active. Now due to sleep-deprivation and the pain, I am not active at all! I have tried an enormous amount of meds. From Gabapentin to anti depressant, Lyica, and acupuncture, epiderials, and, capsacia treatment! Currently I wear Lidoderm for 12hours then I apply a compound of C-ketamine 10%, Gabapentin 6%, and Clonidin 2%! The Lidoderm seems to be the best thing so far! This has been so debilitating, these last 10 months! When the pain comes it is best described as a saw was coming through me and then the rusty old saw was left in me! Due to the pain, I have not worn a bra for 10 months! I would like to know if you have a better idea that I have not tried, that would work! I am at my wits end!

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