Zidovudine (Apo-Zidovudine and Azidothymidine) Side Effects, Indications, Interactions, Dose Prescribing Information

Feb 11, 2011 No Comments by

What is Zidovudine (Apo-Zidovudine and Azidothymidine)?

Zidovudine belongs to category of metabolism inhibited by aspirin, codeirte, morphine, indomethacin, ketoproten, naproxen, oxacepam, lorazepam, cimetidine, clofibrate, dapsone-ribavirine (in vitro) antagonises zidovudine probenecid reduces renal excretion drugs. Zidovudine is a type of metabolism inhibited by aspirin, codeirte, morphine, indomethacin, ketoproten, naproxen, oxacepam, lorazepam, cimetidine, clofibrate, dapsone-ribavirine (in vitro) antagonises
zidovudine probenecid reduces renal excretion.

This drug is commonly sold as Brand Name Apo-Zidovudine.

Indication/Contraindication for use of Zidovudine (Apo-Zidovudine and Azidothymidine)

  • Low neutrophil cell count less than 0.
  • Asymptomatic and symptomatic HIV disease.
  • Low heamoglobin levels (less than 7 75×10 to the power 9/litre lactation 5g/deci litre)

Side Effects of Zidovudine (Apo-Zidovudine and Azidothymidine)

Anorexia, myalgia, insomnia, Nausea, rash, abdorninal pain, fever, anaemia, neutro penia, lucopenia.

Dosage and Prescribing Information for Zidovudine (Apo-Zidovudine and Azidothymidine)

Initially 200 mg 6 times daily. Thereafter 500 mg1500 mg daily in 4-5 divided doses. Children over 3 months: 180 mg/sq m 4 times daily not recommended for children below 3 months.

Drug Interactions of Zidovudine (Apo-Zidovudine and Azidothymidine)

Metabolism inhibited by aspirin, codeirte, morphine, indomethacin, ketoproten, naproxen, oxacepam, lorazepam, cimetidine, clofibrate, dapsone Ribavirine (in vitro) antagonises zidovudine. Probenecid reduces renal excretion.

Precautions while prescribing Zidovudine (Apo-Zidovudine and Azidothymidine)

  • Drug interaction occurs with analgesics especially paracetamol.
  • Hepatic or renal impairment conduct blood tests at least every 2 weeks for the first 3 months of therapy, followed by once every month.
  • Dose adjustment is to be done if anemia or myelosuppression occurs or is present.
Antibiotics

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I am inspired by the numerous stories of patients who have volunteered to participate in clinical trials. I hope that through CureTalk i can increase awareness about clinical trials and new treatments. I will be writing a series of posts to cover this field
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