What is Tolbutamide (Orinase)?
Tolbutamide is a type of hypoglycemic agents. Tolbutamide belongs to category of sulfonylurea compounds drugs.
It is classified as first generation” sulfonylurea, sole significant action being low ering of blood glucose level in normal and noninsulin dependent diabetics, but not in insulin depedent diabetics. Its mechanism of action is like Glibenclamide. Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic drug sold under the brand name Orinase. This drug may be used in the management of type II diabetes if diet alone is not effective. Tolbutamide stimulates the secretion of insulin by the pancreas. A pill taken to lower the level of glucose (sugar) in the blood. Only some people with noninsulin-dependent diabetes take these pills. This drug is commonly sold as Brand Name Orinase.
Indication/Contraindication for use of Tolbutamide (Orinase)
- diabetic coma diabetic metabolic decompensation (ketoacidosis), severe impairment of renal function, hypersensitivity.
- Noninsulin dependent diabetes mellitus (Type II, maturity onset diabetes) whenever dietary treatment alone proves inadequate.
- Insulin dependent diabetes mellitus (Type 1, juvenile diabetes).
Side Effects of Tolbutamide (Orinase)
- Hypersensitivity skin reactions.
- Nausea, sensation of gastric fullness, transient changes of haemotopoietic system.
Dosage and Prescribing Information for Tolbutamide (Orinase)
1.0 gm a single daily dose before breakfast or the first substantial meal. If more than 1.0 gm daily is required, the rest can be taken before the evening meal. Max : 0.52 gm daily.
Drug Interactions of Tolbutamide (Orinase)
Hypoglycaemic effect enhanced by dicoumarol, clofibrate, chloramphenicol & cyclophosphamide & effect reduced by corticos teroids, adrenaline, oral contraceptives & thiazide.
Precautions while prescribing Tolbutamide (Orinase)
- Paediatrics: Should not be used.
- Compliance to diet and regular medication are of utmost importance for success of treatment.
- Elderly: Safe.
- Pregnancy & Lactation: Should not be used.
- Altered alertness and capacity to react may be impaired.
- Driving vehicle or to operate machinery.
- Alcohol might attenuate or potentiate effect of tolbutamide.