Thyroxine Sodium (Eltroxine and synthroid) Side Effects, Indications, Interactions, Dosage Information
What is Thyroxine Sodium (Eltroxine and synthroid)?
Thyroxine sodium belongs to category of levothyroxine sodium drugs. Thyroxine sodium is a type of duplicate concept. Due to failure of thyroid development extreme iodine deficiency or a defect in hormone synthesis symptoms of cretinism are detected during infancy or childhood. Treatment with thyroxine will restore physical growth & developnient and further mental retardation is prevented. Due to deficient production of thyroid hormone leads to excess TSH leading to thyroid enlargement, more efficient trapping of iodide occurs & probably greater proportion of T3 is synthesized resulting in enough hormone production to meet peripheral demands. Thus treatment with thyroxine is replacement therapy in this condition also, despite no overt hypothyroidism.
An International Nonproprietary Name (INN) is the official non-proprietary name given to a pharmaceutical substance or active pharmaceutical ingredient.
This drug is commonly sold as Brand Name Eltroxine.
Indication/Contraindication for use of Thyroxine Sodium (Eltroxine and synthroid)
- Thyrotoxicosis, hypersensitivity.
- Cretinism, adult hypothyroidism, myxoedema coma, nontoxic goiter.
- Papillary carcinoma of thyroid.
Side Effects of Thyroxine Sodium (Eltroxine and synthroid)
Anginal pain, cardiac arrhythmias, palpitation, and cramps in skeletal muscle tachy cardia, diarrhoea, restlessness, excitabilit, headache, flushing, sweating, excessive loss of weight and muscular weakness.
Dosage of Thyroxine Sodium (Eltroxine and synthroid)
Initially 50 -100 mcg daily, before breakfast, and adusted at 34 wks intervals by 50 mcg until normal metabolism is steadily maintained, this may require doses of 150-300 mcg daily over 50 yrs. Max 50 mcg daily Cardiac disease Max 25 mcg daily or 50 mcg on alternate days. For cretinous infants Initially 25mcg daily increasing by 25mcg every 24 wks. Juvenile myxoedema 2.55mcg/ kg/day.
Drug Interactions of Thyroxine Sodium (Eltroxine and synthroid)
Enhances effect of oral anticoagulants. Aspirin and phenytoin enhance effect of thyroxine. Cholestyramine reduces absorption. Arniodarone elevates thyroxine levels.
Precautions while prescribing Thyroxine Sodium (Eltroxine and synthroid)
- Patients with panhypopituitarism or other causes predisposing to adrenal insufficiency may react unfavourably to thyroxine treatment, & it is advisable to initiate corticosteroid therapy before giving thyroxine in these cases.
- Special care is needed when there are symptoms of myocardial insufficiency or ECG evidence of myocardial infarction.