Streptokinase (Kabikinase and Streptase) Side Effects, Indications, Interactions, Dosage Information
What is Streptokinase (Kabikinase and Streptase)?
Streptokinase belongs to category of serine protease drugs. Streptokinase is a type of serine protease. It is obtained from hemolytic Streptococci group C. It is inactive as such, forms a complex with circulating plasminogen which then causes limited proteolysis of plasminogen to plasmin. Plasmin acts directly on fibrin breakirig it down to achieve thrombolysis. It is an enzyme produced by some strains of streptococcus that can liquefy blood clots by converting plasminogen to plasmin; used medicinally in some cases of myocardial infarction and pulmonary embolism. This drug is commonly sold as Brand Name Kabikinase.
Indication/Contraindication for use of Streptokinase (Kabikinase and Streptase)
- Acute myocardial infarction Acute thrombosis of arteries
- Recent streptococcal infections
- Pulmonary embolism
- Recent haemorrhages
- 750,000 1
- Ulcerative colitis
- Severe hypertension, cerebral haemorrhage
- Deep venous & arterial thrombosis in 1 hr
- Deep venous thrombosis
- myocardial infarction: 5 million
- Diabetes mellitus, Acute pancreatic in 6 hrs 1
- bleeding, hepatic or kidney disease.
- Intracoronary: 20,000
- vulmin for 30-90 min
- stat followed by 2000-4000
Side Effects of Streptokinase (Kabikinase and Streptase)
- Febrile reactions, anaphylaxis, fever, haemorrhage.
- Hypotension, arrhythmias.
Drug Interactions of Streptokinase (Kabikinase and Streptase)
Aspirin, dipyridamole, heparin & anticoagulants increase risk of haemorrhage.
Precautions while prescribing Streptokinase (Kabikinase and Streptase)
- Parturition, surgery or invasive procedures within last 10 days.
- Subacute bacterial endocarditis.
- Menstrual bleeding, follow up with menstrual bleeding.