What is Sodium Valproate (Epilim)?
Sodium valproate is a type of anticonvulsants. Sodium valproate belongs to category of valproic acid drugs.
It is a broad spectrum anticonvulsant, producing little sedation or other central effects. Sod. valproate is more potent in blocking Pentylenetetrazol seizures then in modify ing maximal electroshock. It inhibits the establishment of chronic experimental seizure foci & prevents kindling. Drugs action is by potentiating the inhibitory transmitter GABA has been shown to prevent degradation and euronal uptake of GABA. Sodium valproate or evaporate sodium (USAN) is the sodium salt of valproic acid and is an anticonvulsant used in the treatment of epilepsy and bipolar disorder, as well as other psychiatric conditions requiring the administration of a mood stabilizer.
This drug is commonly sold as Brand Name Epilim.
Indication/Contraindication for use of Sodium Valproate (Epilim)
- Potential, alternative adjuvant drug for grandmal, psychomotor and myoclonic & temporal lobe epilepsies of clonazepam.
- Concurrent admin.
- Liver impairment.
Side Effects of Sodium Valproate (Epilim)
- Weight gain, edema, fulminate hepatitis.
- Anorexia, vomiting, drowsiness, ataxia, and tremor.
- Curling & loss of hair, increased blood ammonia, rashes, thrombocytopenia
Dosage and Prescribing Information for Sodium Valproate (Epilim)
Initially 600 mg daily in divided doses; it can be increased by 200 mg daily at 3 days interval untills proper response is achieved.
Drug Interactions of Sodium Valproate (Epilim)
Blood level increased by aspirin and reduced by carbamazepine, phenobarbitone, phenytoin and primidone. Potentiate CNS depressants including alcohol.
Precautions while prescribing Sodium Valproate (Epilim)
- May indicate a false positive test for diabetes in urine sample.
- Mental retarded children with epilepsy.
- Pregnancy & women of child bearing potential.
- Paediatrics: Reduce the dose necessarily.
- Lactation: Should not be used.
- Elderly: Reduce the dose necessarily.
- Periodic blood count & liver function tests
- Pregnancy: Should not be used.
- Major surgery.