What is Prednisolone (Pediapred and Prelone)?
It is four times more potent than drocortisone, also more selective glucocorticoid but fluid retention does not occur with high doses. Drug has intermediate duration of action & causes less pituitary adrenal suppression when a single morning dose or alternate day treatment is given. Prednisolone is the active metabolite of prednisone. A synthetic glucocorticoid steroid, similar to hydrocortisone, used as an anti-inflammatory, immunosuppressive, and antiallergic drug. This drug is commonly sold as Brand Name Pediapred.
Indication/Contraindication for use of Prednisolone (Pediapred and Prelone)
- Allergic, inflammatory, autoimmune diseases, malignancies.
- Live virus immunisation.
- Peptic ulcer.
- Hypersensitivity, systemic infections.
Side Effects of Prednisolone (Pediapred and Prelone)
- Fragile skin.
- Impairment of fluid, electrolyte meta bolic balance, rounded face, supraclavicular hump, obesjty of trunk with relatively thin limbs
- Delayed healing of wounds.
Dosage and Prescribing Information for Prednisolone (Pediapred and Prelone)
560 mg daily in divided doses.
Drug Interactions of Prednisolone (Pediapred and Prelone)
Action blunted by antiepileptics. Rifampicin accelerates metabolism cyclosporine decreases metabolism. Increased bioavailability with oestrogens and oral contraceptives. Lower plasma salicylate levels. Large doses of antacids impair absorption. Increased requirement of insulin and oral hypoglycaemics.
Precautions while prescribing Prednisolone (Pediapred and Prelone)
- Diabetes mellitus, osteoporosis, psychological disorders, glaucoma diverticulitis, myasthenia gravis, hypertension, congestive.
- cardiac failure, renal insufficency.