What is Ornidazole (Dazolic)?
Ornidazole is a type of concomitant administration of oral anticoagulants may increase the risk of hemorrhage due to diminished hepatic metabolism. Ornidazole belongs to category of concomitant administration of oral anticoagulants may increase the risk of hemorrhage due to diminished hepatic metabolism, drugs.
It is a 5 nitroimidazole derivative. Its antimicrobial actions are similar to metronidazole and is used similarly in the treatment of susceptible protozoal infections and prophylaxis of anaerobic bacterial infections.
Ornidazole is a drug that cures some protozoan infections. It is used by the poultry industry. It has been investigated for use in Crohn’s disease after bowel resection. This drug is commonly sold as Brand Name Dazolic.
Indication/Contraindication for use of Ornidazole (Dazolic)
- Severe intestinal and hepatic amoe biasis, giardiasis, trichomoniasis of urogenital tract, bacterial vaginosis, treatment of susceptible anaerobic infections.
- Hypersensitivity to ornidazole and other imidazoles.
Side Effects of Ornidazole (Dazolic)
Nausea, pain in the abdomen, vertigo, headache, skin rash are generally reported.
Dosage and Prescribing Information for Ornidazole (Dazolic)
Amoebiasis: Adults: 500mg twice a day orally for 5 days. Children: 10-25 mg/kg body weight in two divided doses. Amoebic dysentery: Adults: 1.5 gms orally once a day for 3 days. Children: 40 mg/kg body weight, once a day for 3 days. Giardiasis: Adults: 1.5 g, once daily for 12 days. Children: 40mg/kg body weight for 2 days. Trichomoniasis: 1.5 gm once orally or 500mg twice a day for 5 days. Bacterial vaginosis: 3 tablets of 500rng each as a single dose. Or one tablet of 500mg once daily for 5-7 days.
Drug Interactions of Ornidazole (Dazolic)
Concomitant administration of oral anticoagulants may increase the risk of hemorrhage due to diminished hepatic metabolism,
Precautions while prescribing Ornidazole (Dazolic)
- Pregnancy & Lactation: To be used only if the potential benefits justifies the potential risk to foetus/ neonate.
- In patients with ataxia, vertigo and mental confusion, Ornidazole should be given with caution because the drug has been occasionally reported to aggravate neurological complications in patients with central and peripheral ner vous system disorders.