What is Nevirapine (Viramune)?
Nevirapine is a type of antiviral agents. Nevirapine belongs to category of drug allergen drugs.
It is a nonnucleoside reverse transcriptase inhibitor with activity against HIV1. It binds directly to reverse transcriptase and blocks the RNAdependent and DNAdependent DNA polymerase activities by causing a disruption of the enzyme’s catalytic site. The HIV2 reverse transcriptase and human DNA polymerases (such as DNA polymerases a b , y or d ) are not inhibited by nevirapine. A drug prescribed for use in combination with other anti-HIV drugs. Nevirapine can cause a severe rash in some patients. Reports have also associated nevirapine with hepatotoxicity, a condition which can result in liver damage and death.
This drug is commonly sold as Brand Name Viramune.
Indication/Contraindication for use of Nevirapine (Viramune)
- In combination with other antiretroviral agents for the treatment of HIV1 infection.
Side Effects of Nevirapine (Viramune)
Rash and increases in liver function tests, hypersensitivity, mild to moderate, macromolecular emphysematous cutaneous eruptions
Dosage and Prescribing Information for Nevirapine (Viramune)
200 mg tablet daily for the first 14 days (this lead in period should be used because it has been found to lessen the frequency of rash), followed by one 200mg tablet twice daily, in combination with antiretroviral agents.
Drug Interactions of Nevirapine (Viramune)
Rifampin/Rifabutin, Ketoconazole, Oral contraceptives, Methadone.
Precautions while prescribing Nevirapine (Viramune)
- Severe or life threatening hepatotoxicity, impaired renal and hepatic function, pregnancy, lactation.
- Severe, life threatening skin reactions, Stevens Johnson syndrome, toxic epidermal necrosis and hypersensitivity.