Lynestrenol (Exluton) Side Effects, Dosage, Interaction Information

Feb 04, 2010 No Comments by

What is Lynestrenol (Exluton)?

Lynestrenol  is an oral preparation of the synthetic progestagen sharing various common activities with the natural hormone, progesterone. It exerts a strong progestational influence on the endometrium. Lynestrenol suppresses ovulation and menstruation for as long as the preparation is taken daily without interruption.

Lynestrenol is a progestagen (or gestagen) hormone. It is also sold under the brand name Exluton.

Indication/Contraindication for use of Lynestrenol (Exluton)

  • Suppression of menstruation, ovulation and ovulation pain
  • Pre-menstrual syndrome,
  • Benign breast disease.
  • Endometrial hyperplasia.
  • Contraindications :
    • Thrombophlebitis, thromboembolic processes, or a history of these disorders
    • Disturbances of the liver function, jaundice, Roter syndrome and Dubin-Johnson syndrome or a history of jaundice
    • Undiagnosed genital bleeding.
    • Thrombophlebitis, thromboembolic processes, or a history of these disorders

Side Effects of Lynestrenol (Exluton)

  • Headache, migraine, dizziness, nervous ness, breast pain, oedema
  • Disturbances, weight increase
  • Breakthrough bleeding or spotting, change in libido, nausea,

Dosage of Lynestrenol (Exluton)

  • Polymenorrhoea : 5 mg daily on days 14 25.
  • Menorrhagia : 10 mg daily for 10 days repeat for 3 cycles : 5 mg on days 14-25.
  • Endometriosis : 5-10 mg daily for 6 months.
  • Dysmenorrhoea : 5 mg from 15th day for months.
  • Postponement of menstruation : 5 mg daily 2 weeks prior to menstruation if 1 week before then 1015 mg daily. Endometrial hyperplasia : 2.5-5 mg daily for 12-15 days per month.

Drug Interactions of Lynestrenol (Exluton)

The drug may fail in its effect as a contraceptive when taken with phenobarbitone, phenytoin, primidone, carbamazepine, dichloralphenazone, rifampicin and broad spectrum antibiotics. Combination with ethinyloestradiol increases insulin requirement and reduced efficacy of oral anticoagulants.

Precautions while prescribing Lynestrenol (Exluton)

It may cause chloasma, changes in parameters of liver function, carbohydrate metabolism & haemostasis, acne & hirsutism, circulatory disorders, depression.

Hormones

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I am inspired by the numerous stories of patients who have volunteered to participate in clinical trials. I hope that through CureTalk i can increase awareness about clinical trials and new treatments. I will be writing a series of posts to cover this field
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