Loxapine (Loxapac and Loxitane) Side Effects, Dosage, Interaction Information

Feb 19, 2011 No Comments by

What is Loxapine (Loxapac and Loxitane)?

Loxapine is a type of additive cns depression with sedatives, hypnotics, antihistamines and opiates orthostatic hypotension with maols. anti cholinergic effects potentiated by anti Parkinson agents & tricyclic antidepressants antagonises anti hypertensive effect of guanethidine, methyldopa and clonidine. Loxapine belongs to category of antipsychotic agents drugs.

It is dibenzoxazepine which chemically resembles imipramine but has antipsychotic activity like chlorpromazine. Loxapine  is a typical antipsychotic medication, used primarily in the treatment of schizophrenia.

Indication/Contraindication for use of Loxapine (Loxapac and Loxitane)

  • Manifestations of psychotic disorders  individuals with known hypersensitivity to benzodiazepines  in comatose or severe drug induced depression states (alcohol, barbiturates, narcotics, etc).
  • Acute chronic paranoid schizophrenia.

Side Effects of Loxapine (Loxapac and Loxitane)

Insomnia, dizziness, tardivdyskinesia, tachycardia, neuroleg malignant syn drome, hypotension, nausea/vomiting, headache, paresthesia, polydypsia

Dosage and Prescribing Information for Loxapine (Loxapac and Loxitane)

Initial 10 mg twice daily. For severely disturbed : Initial upto 50 mg daily. Increase rapidly in 7-10 days. Usual therapeutic ose : 60-100 mg/day.

Drug Interactions of Loxapine (Loxapac and Loxitane)

Additive CNS depression with sedatives, hypnotics, antihistamines and opiates. Orthostatic hypotension with MAOls. Anticholinergic effects potentiated by antiparkinson agents & tricyclic antidepressants. Antagonises anti hypertensive effect of guanethidine, methyldopa and clonidine.

Precautions while prescribing Loxapine (Loxapac and Loxitane)

  • In patients with history of convulsive disorders.
  • Lactation: Contraindicated ‘ Elderly: Use with caution.
  • Pregnancy: Contraindicated.
  • Paediatrics: Not recommended.
  • CVD, glaucoma, tendency to urinary retention.
Central Nervous System

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