Gemfibrozil (Lopid and Jezil) Side Effects, Indications, Interactions, Dosage Information
What is Gemfibrozil (Lopid and Jezil)?
Gemfibrozil is a type of anticholesteremic agents. Gemfibrozil belongs to category of anticholesteremic agents drugs.
It is a hypolipidemic drug & has action resembling nicotinic acid decreases very low density lipoprotein (VLDL) and Triglyceride levels primarily, Though the crease in total cholesterol may be modest, a more favourable distribution is indicated. Its primary action appears to be reduction of VLDL secretion by liver. Additional decrease in adipose tissue lipolysis and uptake of fatty acids by liver has been demonstrated. Gemfibrozil is the generic name for an oral drug used to lower lipid levels. It belongs to a group of drugs known as fibrates. It is most commonly sold as the brand name, Lopid. Other brand names include Jezil and Gen-Fibro.
Indication/Contraindication for use of Gemfibrozil (Lopid and Jezil)
- Children, severe impair ment of renal & hepatic functions.
- Alcoholism, gall bladder disease.
- Hypersensitivity.
- Hyperlipidaemia, lipoprotein abnormalities resistant to diet alone.
Side Effects of Gemfibrozil (Lopid and Jezil)
- Epigastric distress and loose motions.
- Skin rashes, eosinophilia, bodyache.
- Raised blood sugar, blurred vision, impotence.
Dosage and Prescribing Information for Gemfibrozil (Lopid and Jezil)
900-1500 mg daily (usual dose : 1200 mg) in 2 divided doses 1/2 hr before meals.
Drug Interactions of Gemfibrozil (Lopid and Jezil)
Potentiates anticoagulants.
Precautions while prescribing Gemfibrozil (Lopid and Jezil)
- Regular Ophthalamic checkup required.
- Elderly: Use with caution.
- Conduct blood count, liver function & lipid profile tests before initiating therapy and repeat them periodically.
- Paediatrics: Should not be used.
- Lactation: Should not be used.
- Pregnancy: Should not be used.
- Discontinue if abnor mal liver function persists.
