Capreomycin (Ogostal and Caprocin) Side Effects, Dosage, Interaction Information

Feb 03, 2011 No Comments by

What is Capreomycin (Ogostal and Caprocin)?

Capreomycin belongs to category of antibiotics, aminoglycoside drugs. Capreomycin is a type of anti tuberculosis and antileprosy agents.

It is a second line antimycobacterial drug, and is a bacetericidal agent which exhibits activity against human strains of Mycobacterium tuberculosis. Capreomycin is a peptide antibiotic, commonly grouped with the aminoglycosides, which is given in combination with other antibiotics for tuberculosis. Adverse effects include nephrotoxicity and 8th cranial nerve toxicity. This drug is commonly sold as Brand Name Ogostal.

Indication/Contraindication for use of Capreomycin (Ogostal and Caprocin)

  • Hypersensitivity.
  • Second line drug for concomitant use with other appropriate anti tubercular drugs when he first line drugs are ineffective.

Side Effects of Capreomycin (Ogostal and Caprocin)

Tinnitus, vertigo, leucopenia, hypokalemia, urticaria, skin rash, fever, pain and induration at injection site, abnormalities in liver functions.

Dosage and Prescribing Information for Capreomycin (Ogostal and Caprocin)

1 gm daily intramuscularly, followed by 1g i.m. 2-3 times weekly.

Drug Interactions of Capreomycin (Ogostal and Caprocin)

Co administration of aminoglycoside and other polypeptide antibiotics may increase risk of respiratory paralysis and renal dysfunction. Non depolarising neuromuscular blocking agent enhances neuromuscular blockade due to synergistic effect on myoneural function.

Precautions while prescribing Capreomycin (Ogostal and Caprocin)

  • Lactation: Use with caution.
  • Audiometric, renal function tests and liver function tests must be performed at regular intervals.
  • Paediatrics: Not recommended Pregnanacy: Safety not established.
Antibiotics

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