What is Atenolol And Nifedipine (Tenif and Tenordate)?
Nifedipine reduces hypertension due to peripheral vasodilation and atenolol cornplements this action by reducing cardiac output, counter acting tachycardia and also by reducing renin release. The anti hypertensive efficacy of nifedipine is clearly potentiated by combination with atenolol. Nifedipine reduces angina due to coronary vasodilation and atenolol complements this action by reducing heart rate and cardiac output. The side effects of nifedipine are due to its vasodilatory effects where as those associated with atenolol result from its cardiac effects. This complimentary pharmacodynamic interaction leads to a reduction in some of the adverse reactions of the monotherapies. Nif-Ten combines two medicines that have different ways of working (modes of action). Doctors know that this leads to a greater lowering of blood pressure in some people than with either medicine used alone.This drug is commonly sold as Brand Name Tenif.
Indication/Contraindication for use of Atenolol And Nifedipine (Tenif and Tenordate)
- Sinus bradycardia, heart block greater than first degree, cardiogenic shock, cardiac failure, anuria.
- Hypertension, Angina pectoris.
Side Effects of Atenolol And Nifedipine (Tenif and Tenordate)
Same as for Atenolol & Nifedipine, they are minimised by providing nifedipine in sustained release tablet form and by combining it with Atenolol.
Dosage and Prescribing Information for Atenolol And Nifedipine (Tenif and Tenordate)
Atenolol 50 mg, nifedipine 20 mg (sustained release) each capsule once daily increased to twice daily gradually.
Drug Interactions of Atenolol And Nifedipine (Tenif and Tenordate)
Reduced clearance of disopyramide, antacids reduces bio availability, ampicillin reduces atenolol levels leading to exces sive nifedipine effects, additive vasodilation effects with nitrates.
Precautions while prescribing Atenolol And Nifedipine (Tenif and Tenordate)
- Paediatrics: Not recommended.
- Pregnancy: Contraindicated.
- Diabetics, bronchospastic disease, general anesthesia.
- Lactation: Contraindicated.
- Elderly: Reduce the dose.