What is Amrinone (Inocor and Amcoral)?
Amrinone or inamrinone (USAN, changed in 2000 to prevent confusion with amiodarone), trade name Inocor, is a type 3 pyridine phosphodiesterase inhibitor. It is a drug (trade name Inocor) used intravenously in heart failure; increases strength of contraction of myocardium. Inocor (or inamrinone) is a type 3 pyridine phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure. This drug is commonly sold as Brand Name Inocor.
Indication/Contraindication for use of Amrinone (Inocor and Amcoral)
- Congestive heart failure.
Side Effects of Amrinone (Inocor and Amcoral)
- Cardiac arrhythmia, hepatotoxicity.
- GI disturbances, myositis, nail discoloration, nausea, hypersensitivity, vomiting, thrombocytopenia, chest pain, hypotension, vasculitis, inj, site pain, decreased tear production.
Dosage and Prescribing Information for Amrinone (Inocor and Amcoral)
Adults : Initial loading dose : 0.75mg/kg as slow IV over 23 minutes, followed by maintenance infusion of 510mcg/kg/min. The loading dose may be repeated after 30 minutes, if required. Total max daily dose 10mg/kg. Children : not recommended.
Drug Interactions of Amrinone (Inocor and Amcoral)
Exaggerated hypotension reported with concurrent usage of disopyramide and amrinone. Others : Chemical interaction with precipitation occurs with amrinone and dextrose or frusemide. These drug mixing should be avoided.
Precautions while prescribing Amrinone (Inocor and Amcoral)
- Fluid and electrolyte balance should be maintained; protect ampoules from light, platelet counts and liver function should be monitored, Obstructive pulmonary or aortic disease, hypertrophic cardiomyopathy; BP and heart rate monitored during drug administration.
- Pregnancy and lactation.