Amrinone (Inocor and Amcoral) Side Effects, Indications, Interactions, Dosage Information

Jan 23, 2011 No Comments by

What is Amrinone (Inocor and Amcoral)?

Amrinone or inamrinone (USAN, changed in 2000 to prevent confusion with amiodarone), trade name Inocor, is a type 3 pyridine phosphodiesterase inhibitor. It is a drug (trade name Inocor) used intravenously in heart failure; increases strength of contraction of myocardium. Inocor (or inamrinone) is a type 3 pyridine phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure. This drug is commonly sold as Brand Name Inocor.

Indication/Contraindication for use of Amrinone (Inocor and Amcoral)

  • Hypersensitivity.
  • Congestive heart failure.

Side Effects of Amrinone (Inocor and Amcoral)

  • Cardiac arrhythmia, hepatotoxicity.
  • GI disturbances, myositis, nail discoloration, nausea, hypersensitivity, vomiting, thrombocytopenia, chest pain, hypotension, vasculitis, inj, site pain, decreased tear production.

Dosage and Prescribing Information for Amrinone (Inocor and Amcoral)

Adults : Initial loading dose : 0.75mg/kg as slow IV over 23 minutes, followed by maintenance infusion of 510mcg/kg/min. The loading dose may be repeated after 30 minutes, if required. Total max daily dose 10mg/kg. Children : not recommended.

Drug Interactions of Amrinone (Inocor and Amcoral)

Exaggerated hypotension reported with concurrent usage of disopyramide and amrinone. Others : Chemical interaction with precipitation occurs with amrinone and dextrose or frusemide. These drug mixing should be avoided.

Precautions while prescribing Amrinone (Inocor and Amcoral)

  • Fluid and electrolyte balance should be maintained; protect ampoules from light, platelet counts and liver function should be monitored, Obstructive pulmonary or aortic disease, hypertrophic cardiomyopathy; BP and heart rate monitored during drug administration.
  • Pregnancy and lactation.
Cardiovascular System

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