Amitriptyline (Elavil and Tryptizol) Side Effects, Indications, Interactions, Dose Prescribing Information
What is Amitriptyline (Elavil and Tryptizol)?
Amitriptyline belongs to category of tricyclic antidepressant measurement drugs. Amitriptyline is a type of potentiating sedative effect of alcohol, anti parkinson agents, anti psychotic drugs, increase risk of anticholinergic effects reduce effect of anti hypertensives, marked hyperpyrexia, convulsions & coma with maols potentiating hypertensive effects of sympathomimetics. reduced serum levels with barbiturates neuroleptics inhibit metabolism.
It blocks the neuronal uptake of noradrenaline and exert anticholinergic activity. Drug has marked sedative effect in comparision to Imipramine & is more suitable for depressed patients showing anxiety and agitation. Amitriptyline is approved for the treatment of major depression, as well as clinical/endogenous depression and also involutional melancholia which is no longer seen as a disease in its own right.
Indication/Contraindication for use of Amitriptyline (Elavil and Tryptizol)
- Ischaemic heart disease.
- Childhood bed wetting.
- Cardiovascular sufficiency.
- Depressive illness accompanied by anxiety, agitation, restlessness & disturbances of sleep.
- Masked depression, dysphoria & depression in alcoholics.
- Narrow angle glaucoma.
- Pregnancy, retention of urine, severe liver dysfunction.
Side Effects of Amitriptyline (Elavil and Tryptizol)
- Dry mouth, constipation, epigastric distress, urinary retention, blurred vision, palpitation, sedation & mental confusion, fine tremors, seizure threshold is lowered.
- Postural hypotension.
Dosage and Prescribing Information for Amitriptyline (Elavil and Tryptizol)
10-25 mg initially 3 times a day, increased by 10-25 mg every 2nd or 3rd day till desired results are achieved. Max 150-225 mg daily. Patients over 60 yrs: 10 mg thrice daily initially. Alcoholics : 25 mg 3-4 times daily. Maint. dose : 10-15 mg thrice daily.
Drug Interactions of Amitriptyline (Elavil and Tryptizol)
Potentiates sedative effect of alcohol, antiparkinson agents,antipsychotic drugs, increase risk of anti cholinergic effects. Reduce effect of anti hypertensives, marked hyperpyrexia, convulsions & coma with MAOls. Potentiates hypertensive effects of sympathetics. Reduced serum levels with barbiturates. Neuroleptics inhibit metabolism.
Precautions while prescribing Amitriptyline (Elavil and Tryptizol)
- Pregnancy & Lactation: Contraindicated.
- Renal, hepatic or cardiac disease.
- Ability to drive or operate heavy machinery may be impaired.
- May activate latent schizophrenia.
- Hyperthyroidism, suicidal tendency in seriously depressed patients.
- Elderly: Reduced dose necessary.
- Paediatrics: Not recommended below 6 years.