Adefovir (Hepsera and Preveon) Side Effects, Indications, Interactions, Dose Prescribing Information

Feb 12, 2011 No Comments by

What is Adefovir (Hepsera and Preveon)?

Adefovir belongs to category of antiviral agents drugs. Adefovir is a type of antiviral agents. It belongs to new class of antiviral drugs called nucleotide analogues. Adefovir works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. It is approved for the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum amino transferases  or histologically active disease.

The main benefit of adefovir over lamivudine (the first NRTI approved for the treatment of hepatitis B) is that it takes a much longer period of time before the virus develops resistance to it. It is a nucleotide reverse transcriptase inhibitor that was unsuccessfully tested as an anti-HIV therapy, but is approved to treat chronic hepatitis B. This drug is commonly sold as Brand Name Preveon.

Indication/Contraindication for use of Adefovir (Hepsera and Preveon)

HBeAg positive and negative chronic hepatitis B, Lamivudine resistant HBV HIV co infection, Lamivudine resistant pre transplant & post transplant hepatitis B with decompensated liver disease.

Side Effects of Adefovir (Hepsera and Preveon)

Pharyngitis, headache, asthmatic, abdominal pain, flu like syndrome & nausea.

Dosage and Prescribing Information for Adefovir (Hepsera and Preveon)

10mg per day.

Precautions while prescribing Adefovir (Hepsera and Preveon)

  • Symptoms of Hepatitis B may worsen if adefovir is stopped suddenly.
  • Test for HIV before starting treatment with adefovir.
  • Monitor kidney functions.

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