Acebrophylline (Ambroxol, COPD Medication) Side Effects, Indications, Interactions, Dosage Information

Nov 28, 2010 7 Comments by

What is Acebrophylline (COPD Medication)?

Acebrophylline belongs to category of drug groups primarily affecting the respiratory system drugs. Acebrophylline is a type of alkaloids and it used to treat COPD. Acebrophylline is an air way mucus regulator with anti-inflammatory action.

Acebrophylline has 3 actions namely bronchodilation, mucoregulation & anti-inflammatory action. Unlike other xanthine derivatives it has minimum side effects like palpitations & tachycardia. So all in all it is high on effect and low on side effects. It is manufactured by Molcan Corporation in Canada and is available as Ambroxol.

The therapeutic activity and safety of acebrophylline were evaluated in 50 patients (34 men and 16 women) with chronic obstructive pulmonary disease (COPD). The drug was administered for 10 consecutive days using three formulations—capsules, granulate, and syrup. The effectiveness of acebrophylline was evaluated either on the basis of subjective symptoms and objective findings on the basis of variables of pulmonary function as determined by using spirometry and blood gas analysis before and at the end of treatment. The results showed an early and positive effect of acebrophylline on the quantity and viscosity of expectoration and consequently a marked improvement in signs and symptoms of patients, with favorable changes in respiratory function. Safety and compliance with treatment were very good.

Indication/Contraindication for use of Acebrophylline (COPD Medication)

Acute & Chronic bronchitis, bronchial asthma, sinusitis, dried rhinitis, COPD.

Side Effects of Acebrophylline (COPD Medication)

Epigastric pain.

Dosage of Acebrophylline (COPD Medication)

100 mg Acebrophyllin, twice daily for 14days.

Precautions while prescribing Acebrophylline (COPD Medication)

  • Narrow angle glaucoma,
  • Rescue therapy.
Respiratory System

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7 Responses to “Acebrophylline (Ambroxol, COPD Medication) Side Effects, Indications, Interactions, Dosage Information”

  1. mahendra gunjal says:

    Can i get approved label of this??


  2. Thomas says:

    Can i get a monograph&some notes on advantages over other alkaloids

  3. mahesh says:

    how it is supererar that doxofyline

  4. pankaj sharma says:

    can we use it with a combination of mucolytic.

  5. S K B says:

    I have just started ace brophylline a week ago. I want to know whether it gives any type of after effects

  6. Anil Kesavan says:

    How is it different to plain Ambroxol available in India

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