A protein has been found to occur in aggressive forms of prostate cancer and can be used as potential marker for the same, reports Daily Mail. Scientists at the Liverpool University have discovered a prostate cancer specific protein that could be used for detecting early signs of prostate cancer. The study has been published in the British Journal of Cancer.
Lead author of the study, Chris Foster, says that they have identified a sequence in the PRKCZ gene which has a unique active region. Professor Foster’s previous works have shown that the gene, PRKCZ , is responsible for the aggressiveness of prostate cancer cells. The new study, finds that this gene demonstrates a changed expression in prostate cancer cells and produces a protein which is responsible for the change in cellular behavior.
Professor Chris Foster, from the University of Liverpool, says
We’ve identified a sequence of the PRKCZ gene in prostate cancer cells that is expressed independently from the normal version, and the protein produced by this gene contains a unique active region.
We now need to discover what role this protein is playing in prostate cancer. If it encourages aggressiveness in the disease then we may be able to develop new drugs that reduce its effects.
The research team feels that this gene sequence can be used to detect which patients might be at risk of developing aggressive forms of prostate cancer.
With over two thirds of prostate cancer patients not needing treatment and the USPTF recommending against use of routine PSA test for prostate cancer screening, it becomes important to find biological markers so as to differentiate the aggressive tumors from the indolent ones for better treatment regimens and prognosis.
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