Clinical Trials Investigating Treatments for Preterm Birth

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Preterm Labor is defined as the condition, when expecting women experience labor before 37^th weeks of pregnancy. By this time the baby is not fully grown, so it becomes very critical to keep the baby alive outside of mother’s womb, in case the baby is delivered through Preterm Labor.

Women with certain infections or shortened cervix or being pregnant with multiple babies etc are generally at a higher risk for Preterm Labor. The risk is also higher for those who have already experienced Preterm Labor during their previous pregnancies. Preterm Labor can be identified by the symptoms like abnormal vaginal discharge (water, blood or mucus), pain in lower abdomen, persistent backache, regular contraction of uterus, water broken etc.

Immediate medical support is most essential for women with Preterm Labor. But before that one has to diagnose the problem by judging the symptoms. To judge these symptoms, expecting women require some knowledge on this subject. Once admitted to the health care unit, she needs to be monitored for Preterm Labor. Medications are also given to stop the contractions and delay the delivery process. But one can definitely avoid this situation by being more careful in her pregnancy and taking necessary preventive actions.

To develop more effective treatment methods for Preterm Labor, scientists are conducting several clinical research studies. Clinical trials are medical research studies that are critical in advancing the development of new treatments and procedures and for advancing medical knowledge. Approximately 15 Clinical Trials for Pre-term Birth are currently being performed all across the United States for finding new or improving the understanding of existing treatments for Preterm Birth. Clinical trials are sponsored in a large part by pharmaceutical companies and the federal government agencies like the National Institutes of Health (NIH).

See a list of some of these new treatments and investigators below.

Preterm Birth clinical trials Interventions/Treatments

Delayed Cord Clamping
Standard Expectant Management
Milking Of The Cord
No Interventions.
Individualized Developmental Care In The Nicu
Methadone
Vehicle
Cup Pessary (Bioteque America, Inc)
Immediate Cord Clamping
Nidcap (Newborn Individualized Developmental Care)
Lifestyle Support
Diagnosis By Cervical Length And Fibronectin

Sites/Medical Centers doing Preterm Birth Clinical Trials

Cooper University Hospital
Franklin Square Hospital
Winthrop-University Hospital
Long Beach Memorial Hospital
Waukesha Memorial Hospital
UMCG Dept of OB/GYN
Arkansas Children's Hospital
University of Colorado Hospital
Mount Sinai School of Medicine
LDS Hospital
National Institute of Child Health and Human Development (NICHD), 9000 Rockville
Good Samaritan Hospital

Clinical Trial Investigators for Preterm Birth

Samuel Smith, MD (Franklin Square Hospital)
Graham G Ashmead, MD (Winthrop-University Hospital)
Michael Nageotte, MD (Long Beach Memorial Hospital)
Venkatesh Sampath, MD (Waukesha Memorial Hospital)
Kenneth Trofatter, MD (UMCG Dept of OB/GYN)
Meghan A Donnelly, MD (University of Colorado Hospital)
Xiawei Ou, PhD (Arkansas Children's Hospital)
Keith Eddleman, MD (Mount Sinai School of Medicine)
M Sean Esplin, MD (LDS Hospital)
Peter Scheidt, M.D. (National Institute of Child Health and Human Development (NICHD), 9000 Rockville)
Andrew Combs, MD, PhD (Good Samaritan Hospital)
Laurie Moyer-Mileur, PhD (University of Utah)

List of Clinical Trials for Preterm Birth