The purpose of the study is to directly compare two methods of evaluating heart function at the time of your angiogram. In both methods contrast dye is injected into the main heart chamber during the angiogram while x-ray images are taken. One method uses an automatic power injector to deliver the normal volume of contrast; [...]

The purpose of this study is to evaluate the role of surfactant lung lavage in the treatment of meconium aspiration syndrome. Aspiration of meconium into the tracheo-bronchial tree with the onset of respiration results in meconium aspiration syndrome (MAS). Aspirated meconium inhibits surfactant function directly and also decreases its synthesis by its toxic effects on [...]

The purpose of this is to determine the efficacy and toxicity of proton therapy when used to deliver partial breast radiotherapy in patients with early stage breast cancer with low or intermediate risk factors. Clinical Trial Conditions: Breast Cancer, Early Stage Treatments in this Clinical Trial : Proton Beam Radiotherapy Clinical Trial Phase: Phase 2 [...]

The aim of this study is to investigate effect of whole-body vibration on plasma sclerostin level in healthy young adult women. Fifteen healthy young adult women are planned to include in this study. All cases will be trained on a whole-body vibration (WBV) platform (Power Plate) 5 times a week for one week period. Training [...]

This study is aimed to compare de efficacy and safety of medications currently used in Brazil for treatment of visceral leishmaniasis. We will compare de effects of meglumine antimoniate, two formulations of amphotericin B: deoxycholate and liposomal, and a combination of meglumine plus the liposomal amphotericin B formulation. The study is designed to demonstrate the [...]

The aim of this study is to compare the effectiveness of testosterone,estradiol and a combined treatment with estrogens/progestagens prior to IVF-ICSI in previously diagnosed low responder patients. Clinical Trial Conditions: Ovarian Response Treatments in this Clinical Trial : Testosterone, Estradiol, Ethinylestradiol + Desogestrel, Estrogens, Conjugated (USP) Clinical Trial Phase: Phase 2 Eligible Clinical Trial Participant [...]

The aim of this study is to investigate whether there is a relation between bone mineral density of lower limbs exposed to vibration and the muscle strength gain in the knee extensors and flexors, and a relation serum sclerostin level and the muscle strength gain in the knee extensors and flexors in healthy young adult [...]

We hypothesize that high definition narrow band imaging (NBI) colonoscopy compared to high definition white light colonoscopy will detect an increased number of nonpolypoid (flat and depressed) colorectal neoplasm. Clinical Trial Conditions: Colorectal Neoplasms, Colonic Polyps, Colorectal Cancer Treatments in this Clinical Trial : New High Definition NBI Colonoscopy System Clinical Trial Phase: Phase 3 [...]

Prospective studies to date have identified that the levator ani muscle injuries occur in 14-19% of women after vaginal delivery. In none of studies a vaginal examination was performed at the time of delivery. It has previously been shown that sonographic injuries of the anal sphincter that were believed to be occult were in fact [...]

Many patients who have lumbar degenerative disease suffer from osteoporosis or reduced bone mass or low bone mineral density. Among patients with lumbar degenerative disease, some need fusion surgery. But conditions of osteoporosis or low bone mineral density slow down the rate of bone fusion, reduce the success of bone fusion, and ultimately affect the [...]

An observational clinical study will be performed in subjects aged 12-60 years old to describe the dynamic changes of humoral immune/cellular immunity after vaccination of influenza vaccine, and to discuss the role of different antibodies against influenza virus infection, and to look for possible factors related to side effects with the vaccine. Clinical Trial Conditions: [...]

To investigate safety and tolerance of dose-escalation of infusional recombinant human endostatin in combination with mFOLFOX6 as initial therapy for patients with metastatic colorectal cancer. Clinical Trial Conditions: Colorectal Neoplasm Treatments in this Clinical Trial : recombinant human endostatin (Endostat) Clinical Trial Phase: Phase 1 Eligible Clinical Trial Participant Age : Between 17 years to [...]

Numerous studies demonstrate that patients have improved immediate recovery characteristics following desflurane anesthesia compared to other volatile agents, including sevoflurane. There is limited evidence in the literature to suggest that patients undergoing sevoflurane, compared to desflurane anesthesia, may suffer from limitation in function and cognitive ability for an undetermined, but prolonged period of time following [...]

To obtain a genotypic analysis of patients with chronic exudative age-related macular degeneration noted to have subretinal or intraretinal edema despite continuous monthly Anti-VEGF therapy. Clinical Trial Conditions: Wet AMD Eligible Clinical Trial Participant Age : Between 0 years to 100 years Can Healthy Volunteers Participate: Yes Clinical Trial Lead Sponsor: West Coast Retina Medical [...]

The purpose of this trial is to determine if by structured telephone based health coaching programme supported by remote monitoring system among type 2 diabetes, coronary artery disease and heart failure patients the investigators are able to improve their quality of life as measured by the SF-36 questionnaire and reduce a value of HbA1c under [...]

To investigate the effect of cervical manual mobilization on head repositioning accuracy and postural balance in patients with chronic mechanical neck pain in a randomized controlled trial. Hypothesis: There is no difference between the intervention group (manual mobilization) and control group head repositioning accuracy and postural balance. Clinical Trial Conditions: Neck Pain Treatments in this [...]

The aim of this study is to determine whether inhaled iloprost can be used to prevent and treat PH and PHC while in children after operation of CHD Clinical Trial Conditions: Pulmonary Hypertension Treatments in this Clinical Trial : iloprost nebuliser solusion Eligible Clinical Trial Participant Age : Between 0 years to 12 years Can [...]

The purpose of this study is to evaluate the utility of a minimally invasive nasopharyngeal pH probe for the diagnosis of laryngopharyngeal reflux (LPR) in children with airway compromise; to determine whether it is comparable to the gold standard esophageal pH probe in identifying LPR in this population; and to correlate results of pH testing [...]

This phase IIa study is designed as a multi-centre, single country, randomised, double-blind, placebo controlled study in three parallel groups, with the aim to evaluate the efficacy and safety of Nepadutant given at two oral doses once daily for seven days in comparison to placebo in the treatment of infantile colic. Clinical Trial Conditions: Infantile [...]

The purpose of this protocol is to provide continued acess to immunosuppressive medications to subjects from ITN005CT (NIS01,NCT00014911). Clinical Trial Conditions: Diabetes Mellitus, Type 1 Treatments in this Clinical Trial : Sirolimus, Tacrolimus, Mycophenolate mofetil, Mycophenolic acid Eligible Clinical Trial Participant Age : Between 0 years to 100 years Can Healthy Volunteers Participate: No Clinical [...]

This open-label study will assess the safety, efficacy and pharmacokinetics of RO5323441 in combination with sorafenib in patients with advanced or metastatic hepatocellular carcinoma previously untreated with systemic therapy. In the dose-finding Part I, cohorts of patients will receive escalating doses of RO5323441 intravenously (iv) every 2 weeks in combination with sorafenib 400 mg orally [...]

The purpose of this study is to determine if a new treatment is effective for the treatment of recurrent symptomatic oral herpes virus infections. Clinical Trial Conditions: Oral Herpes Simplex Treatments in this Clinical Trial : BTL TML HSV, Matching placebo Eligible Clinical Trial Participant Age : Between 18 years to 100 years Can Healthy [...]

Anti-mullerian hormone (AMH) has been shown to be a reliable marker of ovarian reserve. In prior studies, tubal ligation has been shown to have an adverse effect on ovarian reserve. One theory postulated for this effect is that the ovarian circulation is disrupted by the procedure, leading to altered hormone production. In this prospective cohort [...]

The purpose of this study is to determine efficacy of SB injection in Hepatocellular Carcinoma (HCC). Clinical Trial Conditions: Hepatocellular Carcinoma Treatments in this Clinical Trial : SB injection Clinical Trial Phase: Phase 2 Eligible Clinical Trial Participant Age : Between 18 years to 100 years Can Healthy Volunteers Participate: No Clinical Trial Lead Sponsor: [...]

The aim of the study is to compare the safety & efficacy of sertraline (up to a dose of 200mg/day) & pregabalin (up to a dose of 300mg/day)for the treatment of symptoms of anxiety in patients with epilepsy. Clinical Trial Conditions: Epilepsy, Anxiety Treatments in this Clinical Trial : Pregabalin-Lyrica, Sertraline Clinical Trial Phase: Phase [...]