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A Study of the Effects of PEITC on Oral Cells With Mutant p53

Feb 14, 2013 No Comments by

The aim of this clinical trial is to examine the effects of phenethyl isothiocyanate
(PEITC), a compound derived from cruciferous vegetables, on oral cells with mutant p53. The
p53 protein's normal (wild-type) function within cells is to act as a tumor suppressor, or
anti-cancer protein. When mutated, the p53 protein not only no longer executes the
functions of a tumor suppressor, and it can gain functions as a pro-cancer protein.22 The
proposed clinical trial will utilize oral cells collected from subjects who are heavy
smokers. Since the subjects are regularly exposed to mutagenic chemicals it is the thought
that their oral cells will contain measurable levels of mutant p53. The participants will
consume watercress juice, which is rich in PEITC (See Figure 1). Previous studies in the
laboratory showed PEITC selectively depletes mutant p53, and not wild type p53, in cell
culture. Our hypothesis is that the ITC in the watercress juice will lead to the depletion
of mutant p53 within the oral cells. This depletion could lead to a possible clinical
application of this compound, such as chemopreventives or oncologic treatments of
individuals with oral cancers.

Clinical Trial Conditions: Oral Cancer

Treatments in this Clinical Trial : Watercress Juice

Eligible Clinical Trial Participant Age : Between 20 years to 65 years

Can Healthy Volunteers Participate: No

Clinical Trial Lead Sponsor: Georgetown University

Detailed Clinical Trial Description: The aim of this clinical trial is to examine the effects of phenethyl isothiocyanate
(PEITC), a compound derived from cruciferous vegetables, on oral cells with mutant p53. The
p53 protein's normal (wild-type) function within cells is to act as a tumor suppressor, or
anti-cancer protein. When mutated, the p53 protein not only no longer executes the
functions of a tumor suppressor, and it can gain functions as a pro-cancer protein.22 The
proposed clinical trial will utilize oral cells collected from subjects who are heavy
smokers. Since the subjects are regularly exposed to mutagenic chemicals it is the thought
that their oral cells will contain measurable levels of mutant p53. The participants will
consume watercress juice, which is rich in PEITC (See Figure 1). Previous studies in the
laboratory showed PEITC selectively depletes mutant p53, and not wild type p53, in cell
culture. Our hypothesis is that the ITC in the watercress juice will lead to the depletion
of mutant p53 within the oral cells. This depletion could lead to a possible clinical
application of this compound, such as chemopreventives or oncologic treatments of
individuals with oral cancers.

The clinical trial information was obtained from http://clinicaltrials.gov/ct2/show/NCT01790204

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By: ifood.tv