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Hyperthermia and the Amelioration of Autism Symptoms

Feb 06, 2013 No Comments by

The febrile hypothesis of Autism Spectrum Disorder (ASD) stems from the observation that
clinical symptoms improve during fever. This fever induced amelioration of symptoms could be
due to one of three possible causes, (1) the direct effect of temperature; (2) a resulting
change in the immune inflammatory system function associated with the infection or fever;
and/or (3) and increase in the functionality of a previously dysfunctional Locus
Coeruleus-Noradrenerigic (LC-NA) system. Little has been done to explore the potential
direct effect an increased body temperature may have on autism symptomology. Parental
reports have demonstrated that during febrile episodes children with ASD have improved
social cognition and language skills, and decreased disruptive behaviors. In order to
further explore the direct temperature effect, further investigation is needed, which the
investigators propose below. The investigators propose to complete a one year double blind
crossover study with 15 children with ASD between the ages of 5 and 17 years old. Five
children with ASD will complete a control protocol prior to beginning the full protocol with
10 additional ASD children. This will allow for any needed amendment of protocol
parameters prior to completion of the full protocol.

Clinical Trial Conditions: Autism Spectrum Disorder

Treatments in this Clinical Trial : Hydroworx Pool at 98 degrees Fahrenheit, Hydroworx Pool at 102 degrees Fahrenheit

Eligible Clinical Trial Participant Age : Between 5 years to 17 years

Can Healthy Volunteers Participate: No

Clinical Trial Lead Sponsor: Montefiore Medical Center

Detailed Clinical Trial Description: The febrile hypothesis of Autism Spectrum Disorder (ASD) stems from the observation that
clinical symptoms improve during fever. This fever induced amelioration of symptoms could be
due to one of three possible causes, (1) the direct effect of temperature; (2) a resulting
change in the immune inflammatory system function associated with the infection or fever;
and/or (3) and increase in the functionality of a previously dysfunctional Locus
Coeruleus-Noradrenerigic (LC-NA) system. Little has been done to explore the potential
direct effect an increased body temperature may have on autism symptomology. Parental
reports have demonstrated that during febrile episodes children with ASD have improved
social cognition and language skills, and decreased disruptive behaviors. In order to
further explore the direct temperature effect, further investigation is needed, which the
investigators propose below. The investigators propose to complete a one year double blind
crossover study with 15 children with ASD between the ages of 5 and 17 years old. Five
children with ASD will complete a control protocol prior to beginning the full protocol with
10 additional ASD children. This will allow for any needed amendment of protocol
parameters prior to completion of the full protocol.

The clinical trial information was obtained from http://clinicaltrials.gov/ct2/show/NCT01784744

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By: ifood.tv