Cardiovascular Diseases in HIV-infected Patients HIV-HEART Study: 7.5 Years Follow-up
Since the introduction of antiretroviral therapy life expectancy of HIV-infected persons is
rising. Different cohorts are observing an increased risk for cardiovascular diseases in
this aging HIV-infected population. Traditional cardiovascular risk factors like smoking are
more frequent in HIV-infected persons. For example chronic inflammation due to HIV-infection
and metabolic disorders also caused by some antiretroviral substances as special
non-traditional risk factors in HIV-infected persons can influence the development of
cardiovascular diseases additionally. Therefore new research focus in special risk profile
associated with HIV-infection or antiretroviral treatment and prevention for HIV-infected
patients is developing.
This present study is an ongoing prospective regional multicenter trial that was conducted
to analyse the incidence, prevalence and clinical course of cardiovacular disorders in
HIV-infected out-patients.
Cardiac disorders witch are associated with HIV are pericarditis, pleural effusion,
pulmonary hypertension, dilated cardiomyopathy, heart failure, myocarditis, bacterial
endocarditis and heart valve disorders. In addition to previously stated disorders of the
heart, the premature atherosclerosis of coronary arteries, a further even more important
disease of the heart in this patient population, went into the focus of most HIV-researchers
and physicians.
Clinical Trial Conditions: Coronary Heart Disease, Heart Failure, HIV, AIDS, Metabolic Syndrome
Treatments in this Clinical Trial : Comprehensive non invasive cardiovascular examination
Eligible Clinical Trial Participant Age : Between 18 years to 100 years
Can Healthy Volunteers Participate: No
Clinical Trial Lead Sponsor: University Hospital, Essen
Detailed Clinical Trial Description: Since the introduction of antiretroviral therapy life expectancy of HIV-infected persons is
rising. Different cohorts are observing an increased risk for cardiovascular diseases in
this aging HIV-infected population. Traditional cardiovascular risk factors like smoking are
more frequent in HIV-infected persons. For example chronic inflammation due to HIV-infection
and metabolic disorders also caused by some antiretroviral substances as special
non-traditional risk factors in HIV-infected persons can influence the development of
cardiovascular diseases additionally. Therefore new research focus in special risk profile
associated with HIV-infection or antiretroviral treatment and prevention for HIV-infected
patients is developing.
This present study is an ongoing prospective regional multicenter trial that was conducted
to analyse the incidence, prevalence and clinical course of cardiovacular disorders in
HIV-infected out-patients.
Cardiac disorders witch are associated with HIV are pericarditis, pleural effusion,
pulmonary hypertension, dilated cardiomyopathy, heart failure, myocarditis, bacterial
endocarditis and heart valve disorders. In addition to previously stated disorders of the
heart, the premature atherosclerosis of coronary arteries, a further even more important
disease of the heart in this patient population, went into the focus of most HIV-researchers
and physicians.
The clinical trial information was obtained from http://clinicaltrials.gov/ct2/show/NCT01667068
