By: ifood.tv

Multi-institutional Prospective Research of Expanded Multi-antigen Specifically Oriented Lymphocytes for the Treatment of VEry High Risk Hematopoietic Malignancies

Jul 30, 2014 No Comments by

This Phase I dose-escalation trial is designed to evaluate the safety of administering rapidly-generated multi-antigen-specific T lymphocytes, to HSCT recipients (group A) or future HSCT recipients (group B) for the treatment or relapsed or refractory hematopoietic malignancies. Clinical Trial Conditions: Relapsed/Refractory Hematopoietic Malignancies Treatments in this Clinical Trial : Tumor associated antigen lymphocytes (TAA-CTL) Clinical [...]

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Phase II Study of 5-azacytidine Maintenance After Transplant for AML or MDS

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Despite improvements in outcomes after Hematopoietic Cell Transplantation (HCT) for Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS), the risk of relapse remains high and is the most common cause of mortality after HCT. Moreover, treatment options for relapse after HCT are limited. Strategies to reduce relapse with maintenance therapy in patients who are at [...]

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Safety Study of Chimeric Antigen Receptor Modified T-cells Targeting NKG2D-Ligands

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In this Phase I clinical trial, the investigators will be evaluating if it is safe and feasible to give T cells expressing a chimeric NKG2D receptor to patients. We will also look to see if the T cells have a beneficial effect against tumors expressing NKG2D ligands and learn more about the persistence and the [...]

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Comparing NAAT Testing to Standard Methods for the Diagnosis of Vaginitis

Jul 30, 2014 No Comments

Vaginitis is the most common condition encountered in the gynecologist's office and is most commonly caused by bacerial vaginosis (BV), vulvovaginal candidiasis (VVC) and Trichomonas vaginalis (TV). Establishing the correct etiology of symptomatic vaginitis can be challenging, and the evaluation of vaginitis by physicians is often substandard. The investigators will determine whether NAAT testing will [...]

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Exercise Behavior Among Young Adults Study

Jul 30, 2014 No Comments

The rate of adult obesity in the United States has increased more than two times since 1970, and the rate of child-teen obesity has increased by four times. One of the antecedents of obesity is an inactive lifestyle. Exercise has been known to be associated with increases in both physical and mental health by increasing [...]

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Treatment of Infertility by Collagen Scaffold Loaded With Autologous Bone Marrow Stem Cells

Jul 30, 2014 No Comments

Study of the treatment of infertility caused by severe intrauterine adhesions or endometrial dysplasia by collagen scaffold loaded with autologous bone marrow stem cells, and to provide clinical evidence for the treatment of uterine infertility Clinical Trial Conditions: Infertility, Intrauterine Adhesions, Endometrial Dysplasia Treatments in this Clinical Trial : autologous bone marrow stem cells Clinical [...]

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Effect of Probiotic Lozenge on Gingivitis and Periodontitis

Jul 30, 2014 No Comments

The oral cavity is mostly influenced by general health. The oral microbiota which is as complex as the gastro-intestinal or vaginal microbiota are considered to be difficult therapeutic targets. The effects of probiotics in different fields of health care have resulted recently in the introduction of probiotics for oral healthcare. Probiotics have been clinically proved [...]

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Timing of Meals for Weight Loss

Jul 30, 2014 No Comments

While eating the majority of energy earlier in the day appears to have a positive effect on weight and cardiometabolic outcomes, it is not clear how eating earlier in the day influences other behaviors that have a circadian rhythm (sleep), other energy balance behaviors important for weight loss (physical activity), and self-reported feelings of appetite [...]

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Cochlear Implantation in Single Sided Deafness and Asymmetrical Hearing Loss: a Cost/Utility Study.

Jul 30, 2014 No Comments

The investigators assume that cochlear implants in this indication are not only effective but also cost-effective. The investigators' experimental protocol relies on real life therapeutic strategy, where a cochlear implant may be proposed once CROS and bone conductions systems have failed. Thus, all subjects enrolled in our study will try CROS and bone conduction devices. [...]

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Kinematic Analysis: Posterior Stabilized Fixed Bearing Total Knee Arthroplasty With Attune Knee System

Jul 30, 2014 No Comments

A better understanding of knee joint kinematics is important to explain the premature polyethylene wear failures within total knee arthroplasties (TKAs) and to help design a prosthesis that most closely approximates the normal knee. Specifically, posterior stabilizing (PS) knees have been found to be associated with lower amounts of posterior femoral rollback, higher occurrence of [...]

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Facet Wedge Post Market Study

Jul 30, 2014 No Comments

A Multi-centre, Prospective, single-arm post market clinical follow up study (PMCF) of the FACET WEDGETM spinal system to assess outcomes in subjects with chronic low back pain due to Degenerative Disc Disease (DDD), facet joint disease and/or pseudo arthrosis post anterior instrumentation. The objective of this study is to assess outcomes following implantation of the [...]

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Cardiac Rehabilitation Peer Mentorship

Jul 30, 2014 No Comments

The current study is a randomized controlled trial, being conducted at two hospitals in Toronto, Ontario, Canada, involving the randomization of cardiac inpatients into an intervention group, in which they will receive mentorship from a volunteer cardiac rehabilitation peer mentor, and a control group, in which they will receive usual care. Patients in both groups [...]

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Peanut Oral Immunotherapy in Children With Peanut Allergy

Jul 30, 2014 No Comments

Many children who are allergic to peanuts do not outgrow their allergy and have very severe allergic reactions called anaphylaxis. Symptoms of anaphylaxis include difficulty breathing, decreased blood pressure, hives, and lip or throat swelling after exposure to an allergen. A severe allergic reaction can lead to death if not treated appropriately. The purpose of [...]

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Preoperative Progression of Macular Holes

Jul 30, 2014 No Comments

Knowledge of the natural history and progression of macular holes is mainly limited to the studies from the pre-optical coherence tomography era. By observing macular holes preoperatively we are able to determine the extent of the preoperative macular hole progression. At our institution macular holes are treated in an elective setting. The majority of macular [...]

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Azilsartan Medoxomil (TAK-491) Compared to Placebo in Korean Adults With Hypertension

Jul 30, 2014 No Comments

The purpose of this study is to compare the antihypertensive effect of azilsartan medoxomil versus placebo in Korean adults with essential hypertension. Clinical Trial Conditions: Hypertension Treatments in this Clinical Trial : Azilsartan medoxomil, Azilsartan medoxomil placebo Clinical Trial Phase: Phase 3 Eligible Clinical Trial Participant Age : Between 19 years to 100 years Can [...]

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Expanded Treatment Prot of Panobinostat in Combo w/ Bortez and Dex in Pts w/ Relapsed and/or Refractory Multiple Myeloma

Jul 30, 2014 No Comments

This will be a multi-center, open label, expanded treatment protocol of panobinostat, bortezomib and dexamethasone in patients with relapsed and/or refractory multiple myeloma. Panobinostat will be administered at a starting dose of 20mg orally three times a week (every other day) for two weeks on and one week off, with dose adjustments permitted based on [...]

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Real Time 3D Imaging and Surrogate Bone Model

Jul 30, 2014 No Comments

This is an observer-blinded prospective randomized clinical trial to define the efficacy of a new technology developed at the Cleveland Clinic to improve the positioning of the acetabular shell in total hip arthroplasty.The proposed study will enroll patients that have consented to total hip arthroplasty with or without screw fixation for treatment of hip pathology. [...]

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The Effect of Continuous Glucose Monitoring on Glycemic Control in Insulin-requiring Gestational Diabetes Mellitus

Jul 30, 2014 No Comments

The purpose of this study is to determine if professional Continuous glucose monitoring improves glycemic control with less hypoglycaemia in insulin-requiring Gestational Diabetes Mellitus Clinical Trial Conditions: Gestational Diabetes Mellitus Treatments in this Clinical Trial : Continuous Glucose Monitoring System Eligible Clinical Trial Participant Age : Between 18 years to 100 years Can Healthy Volunteers [...]

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High-Dose Aldesleukin and Ipilimumab in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed By Surgery

Jul 30, 2014 No Comments

This phase II trial studies how well high-dose aldesleukin and ipilimumab works in treating patients with stage III-IV melanoma that cannot be removed by surgery. Biological therapies, such as aldesleukin, may stimulate or suppress the immune system in different ways and stop tumor cells from growing. Monoclonal antibodies, such as ipilimumab, interfere with the ability [...]

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Proton Beam Radiation Therapy in Treating Patients With Recurrent Thoracic Cancer Who Have Received Prior Radiation Therapy

Jul 30, 2014 No Comments

This pilot clinical trial studies proton beam radiation therapy in treating patients with thoracic cancer that has come back and have received prior radiation therapy. Proton beam radiation therapy uses high energy protons to kill tumor cells and may cause less damage to normal tissue. Clinical Trial Conditions: Lung Metastases, Recurrent Malignant Mesothelioma, Recurrent Non-small [...]

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FBnTP Imaging of Breast Cancer

Jul 30, 2014 No Comments

Our preclinical studies suggest the capacity of the positron emission tomography imaging agent 18F-fluorobenzyl triphenyl phosphonium (FBnTP) to detects early-stage small breast tumors (e.g., DCIS), and differentiates benign from malignant masses with better accuracy than that obtained by existing breast imaging tools. Clinical Trial Conditions: Breast Cancer Treatments in this Clinical Trial : FBnTP Clinical [...]

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To Define the Role of GLP-1 for Improving Glucose Homeostasis in Humans Following Gastric Bypass Surgery

Jul 30, 2014 No Comments

There is a marked and long-lasting improvement in glucose homeostasis that follows Roux-en-y gastric bypass surgery (RYGB) in humans. This improvement has been attributed in large part to an intestinal hormone, called GLP-1, that is released into the circulation immediately after eating. The purpose of this study is to determine if GLP-1 mediates the beneficial [...]

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Long Term Study of RBP 7000 in the Treatment of Subjects With Schizophrenia

Jul 30, 2014 No Comments

This is a Phase 3, open label study administering RBP-7000 in the treatment of patients with schizophrenia. Study will assess the long-term safety and tolerability of RBP-7000 subcutaneous (SC) injections in subjects with schizophrenia and to continue collecting clinical outcome data with RBP-7000 SC injections in subjects with schizophrenia using the Positive and Negative Syndrome [...]

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Dakin’s Solution in Preventing Radiation Dermatitis in Patients With Breast Cancer Undergoing Radiation Therapy

Jul 30, 2014 No Comments

This pilot clinical trial studies Dakin's solution in preventing radiation dermatitis in patients with breast cancer undergoing radiation therapy. Radiation dermatitis is a skin condition in which the affected skin becomes painful, red, itchy, and blistered. Dakin's solution may help reduce dermatitis caused by radiation therapy. Clinical Trial Conditions: Breast Cancer, Skin Reactions Secondary to [...]

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Omega-3 Fatty Acid Supplementation to Stimulants in Children With Attention Deficit Hyperactivity Disorder and Deficient Emotional Self-Regulation

Jul 30, 2014 No Comments

This study is a 12-week open-label trial to assess the effectiveness of Omega-3 fatty acids for deficient emotional self-regulation (DESR) as a supplement to stimulants in children and adolescents with Attention Deficit/Hyperactivity Disorder. Subjects will be between the ages of 6-17 and will currently be on traditional stimulant medication for their Attention Deficit/Hyperactivity Disorder but [...]

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By: ifood.tv