By: ifood.tv

Efficacy and Safety Study of Guselkumab in the Treatment of Participants With Active Psoriatic Arthritis (PsA)

Dec 18, 2014 No Comments by

The purpose of this study is to evaluate the efficacy, safety and tolerability of guselkumab in participants with Active Psoriatic Arthritis (PsA). Clinical Trial Conditions: Psoriatic Arthritis Treatments in this Clinical Trial : Guselkumab, Ustekinumab, Placebo Clinical Trial Phase: Phase 2 Eligible Clinical Trial Participant Age : Between 18 years to 100 years Can Healthy [...]

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Jakarta Acute Coronary Syndrome Registry

Dec 18, 2014 No Comments by

Jakarta acute coronary syndrome enrolled patients with acute coronary syndrome admitted to the emergency department of a national cardiac referral hospital. Clinical Trial Conditions: Acute Coronary Syndrome Treatments in this Clinical Trial : JAC Registry Eligible Clinical Trial Participant Age : Between 18 years to 80 years Can Healthy Volunteers Participate: No Clinical Trial Lead [...]

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Antimicrobial Agent for Reducing Bacteria in Aerosols and Oral Cavity

Dec 18, 2014 No Comments by

The primary objective of this study will be to evaluate the effect of two week pre-surgical rinsing with an antimicrobial mouthrinse containing 0.2% w/v Chlorhexidine digluconate on the total number of plaque bacteria in the mouth 3 days post implant surgery. The study will be conducted at Eastman Clinical Investigation Centre (ECIC), University College London [...]

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Reminiscence Anxiety and Early Alzheimer’s Disease

Dec 18, 2014 No Comments

This study seeks to establish the acceptability and evaluate the limited efficacy of Simple Reminiscence (SR), a home-delivered non-pharmacological intervention designed to relieve stress, improve affect, and prevent or quell disruptive or maladaptive behaviors in community-residing individuals diagnosed with early Alzheimer's disease (EAD). Unmanaged episodes of anxiety can be antecedents of maladaptive behaviors, including agitation, [...]

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Reducing the Risk of Alarm Fatigue Through the Use of Focused Management in Safety Huddles

Dec 18, 2014 No Comments

Context: Alarm fatigue is a threat to hospital patient safety. National surveys reveal that high alarm rates interrupt patient care, reduce trust in alarms, and lead clinicians to disable alarms entirely. Safety huddles offer an appropriate forum for reviewing alarm data and identifying patients whose high alarm rates may necessitate safe tailoring of alarm limits. [...]

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Does Dietary Nitrate Supplementation Improve Aerobic Performance

Dec 18, 2014 No Comments

The purpose of this study is to determine whether dietary nitrate supplementation improves performance in cardiopulmonary exercise testing (CPET). Clinical Trial Conditions: Colorectal Cancer Treatments in this Clinical Trial : Beetroot juice, Placebo beetroot juice Eligible Clinical Trial Participant Age : Between 18 years to 100 years Can Healthy Volunteers Participate: No Clinical Trial Lead [...]

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An Open-label Extension Study of Certolizumab Pegol in Chinese Patients With Rheumatoid Arthritis Who Enrolled in RA0044

Dec 18, 2014 No Comments

This study will continue to evaluate the safety & efficacy of Certolizumab Pegol (CZP) for 6 months in Chinese subjects with active Rheumatoid Arthritis who participated in RA0044. Clinical Trial Conditions: Rheumatoid Arthritis Treatments in this Clinical Trial : Certolizumab pegol Clinical Trial Phase: Phase 3 Eligible Clinical Trial Participant Age : Between 18 years [...]

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Hashimoto – a Surgical Disease. Absolute Total Thyroidectomy Makes Antibodies Disappear and Ameliorates Symptoms

Dec 18, 2014 No Comments

The investigators have already proven that absolute total thyroidectomy gives elimination of anti-TPO antibodies. Our hypothesis is that this elimination also eliminates the typical Hashimoto symptoms, namely: Serious tiredness, increased need of sleep, pain in musculature and joints and dryness in eyes and mouth. The prerequisite for this effect is the absolute total thyroidectomy. There [...]

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Study to Evaluate the Safety Tolerability and Pharmacokinetics of DS-3032b in Hematological Malignancies

Dec 18, 2014 No Comments

This will be a Phase 1, open-label study of DS-3032b to assess its safety and tolerability and identify a Maximum Tolerated Dose (MTD)/tentative Recommended Phase II Dose (RP2D) in subjects with refractory or relapsed Acute Myelogenous Leukemia (AML), Acute Lymphocytic Leukemia (ALL), Chronic Myelogenous Leukemia (CML) in blast phase, or high risk MDS in Part [...]

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Topical Clobetasol for the Treatment of Toxic Epidermal Necrolysis

Dec 18, 2014 No Comments

The primary objectives of this study are to investigate the efficacy and safety of topical steroid ointment (clobetasol 0.05%) for the treatment of the cutaneous manifestations of toxic epidermal necrolysis (TEN). Clinical Trial Conditions: Toxic Epidermal Necrolysis Treatments in this Clinical Trial : Clobetasol 0.05% ointment Eligible Clinical Trial Participant Age : Between 7 years [...]

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Pilot Study: Ostom-i Alert Sensor

Dec 18, 2014 No Comments

The purpose of this study is to determine the usability and acceptance of the Ostom-i Alert Sensor. The investigators would like to see if is generally helpful to ostomy patients and whether it has a beneficial impact on living with an ostomy bag. Results from this study will be used to determine if a larger [...]

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Muscle Ultrasound for Sarcopenia Leading to Early Detection

Dec 18, 2014 No Comments

Sarcopenia is an age-related loss of muscle mass that may affect over 25% of individuals over the age of 60 and results in a 3 to 4 times increased likelihood of developing a disability. Despite these observations, sarcopenia is rarely subject to a systematic screening process as a part of customary geriatric care. Furthermore, when [...]

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Evaluation of the Pharmacokinetic Profile of Tranexamic Acid After Injection in a Knee Neo-articulation.

Dec 18, 2014 No Comments

Evaluate the pharmacokinetic profile of tranexamic acid injected intra-articularly with or without adrenaline, in a population of patients undergoing knee replacement. Clinical Trial Conditions: Knee Prosthesis Treatments in this Clinical Trial : Tranexamic Acid, Adrenalin Eligible Clinical Trial Participant Age : Between 18 years to 80 years Can Healthy Volunteers Participate: No Clinical Trial Lead [...]

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A Phase I/IIa Study of RS1 Ocular Gene Transfer for X-linked Retinoschisis

Dec 18, 2014 No Comments

Objective: To evaluate the safety and tolerability of ocular RS1 AAV vector (AAV8-scRS/IRBPhRS) gene transfer to the retina of participants affected with X-linked juvenile retinoschisis (XLRS). Study Population: Up to 100 male participants with XLRS will be screened under this protocol. Nine male participants affected with XLRS will receive ocular gene transfer, with three participants [...]

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PARP Inhibitor BMN-673 Carboplatin and Paclitaxel in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

Dec 18, 2014 No Comments

This phase I trial studies the side effects and best dose of poly (ADP-ribose) polymerase 1 (PARP) inhibitor BMN-673 when given together with carboplatin and paclitaxel in treating patients with solid tumors that have spread to other places in the body or cannot be removed by surgery. PARP inhibitor BMN-673 may stop the growth of [...]

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Alisertib and Combination Chemotherapy in Treating Patients With Gastrointestinal Tumors

Dec 18, 2014 No Comments

This phase I trial studies the side effects and best dose of alisertib when given together with combination chemotherapy in treating patients with gastrointestinal tumors. Alisertib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as fluorouracil, leucovorin calcium, oxaliplatin, work in [...]

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A Study of RO6927005 Either As Monotherapy (Part A) or in Combination With Gemcitabine and Nab-Paclitaxel (Part B) to Evaluate the Safety Tolerability Pharmacokinetics and Preliminary Clinical Activity in Patients With Mesothelin-positive Metastat…

Dec 16, 2014 No Comments

This is a first-in-human, open-label, multi-center, Phase 1 study of RO6927005. The study will establish the safety and tolerability profile of RO6927005 and will be conducted in two parts. In Part A, the first dose escalations will be carried out using cohorts of 1 patient. Single patient cohorts will be used to investigate increasing doses [...]

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Amyloid Plaque Deposition in Chemotherapy-Induced Cognitive Impairment

Dec 16, 2014 No Comments

The initial goal of the investigators interdisciplinary group of imagers, oncologists, neurologists, neuro-psychologists, and biostatisticians is to obtain proof of concept pilot data for eventual submission of a National Cancer Institute Quick-Trial for Imaging and Image-Guided Interventions: Exploratory Grant (R10) depending on the results of this pilot study. The overall objective is to use [18F]Flutemetamol, [...]

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Gender Effects of Dietary Omega-3 Fatty Acids From Plant and Marine Sources on Oxylipins in Healthy Humans

Dec 16, 2014 No Comments

This study is single site, double-blind, randomized, cross-over study designed to compare the effects of flax oil and fish oil supplementation on the oxylipin profile in healthy males and females. Eligible participants will complete two (2) Supplementation Phases (flax oil versus fish oil) and will be asked to attend 6 in-person clinic visits (0, 1, [...]

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Predisposing Factors Associated With Chemotherapy Toxicity in Elderly Cancer Patients

Dec 16, 2014 No Comments

These days, there is higher proportion of elderly cancer patients. Most of them have comorbidities, borderline performance status and nutritional status. The discontinuation of chemotherapy due to unbearable toxicities was not uncommon. Comprehensive geriatric assessment might be beneficial in selection of suitable elderly patients for chemotherapy administration. Clinical Trial Conditions: Cancer Patient Eligible Clinical Trial [...]

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Investigation for Clinical Efficacy and Safety of Ipragliflozin 50mg and 100mg on Type II Diabetes

Dec 16, 2014 No Comments

The purpose of this study is to evaluate clinical efficacy and safety of Sodium Glucose Co-transporter 2 (SGLT2) inhibitor, ipragliflozin, at doses of 50mg and 100mg, for Type II Diabetes under usual care. It is also to investigate and analyze the exploratory influential factor of ipragliflozin treatment on clinical efficacy and safety. Clinical Trial Conditions: [...]

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A Study of LY900014 Formulations in Healthy Participants

Dec 16, 2014 No Comments

This study evaluates four test formulations of a glucose lowering drug (LY900014) administered by injection under the skin of the abdomen. The study will be conducted in healthy people to investigate how the human body handles LY900014 and the effect of LY900014 on blood sugar levels. Side effects and tolerability will be documented. The study [...]

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Treatment of Binge Eating Disorder in Obesity: Naltrexone/ Bupropion Combination Versus Placebo

Dec 16, 2014 No Comments

This study will test the effectiveness of the combination of Naltrexone and Bupropion relative to placebo for reducing binge eating in persons with obesity and binge eating disorder. Clinical Trial Conditions: Binge Eating Disorder Treatments in this Clinical Trial : Naltrexone and bupropion combination, Pill Placebo Eligible Clinical Trial Participant Age : Between 21 years [...]

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Effect of Use of Straw on Tolerability and Quality of Split Dose 4l-PEG Preparation

Dec 16, 2014 No Comments

The purpose of this study is to determine whether patients drinking their bowel preparation solution with a straw will have improved tolerability for ingestion of their bowel preparation solution and achieve a higher bowel preparation quality score than patients drinking their bowel preparation solution without a straw. Clinical Trial Conditions: Colon Cancer Treatments in this [...]

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Adult Subjects With Uncontrolled Type 2 Diabetes

Dec 16, 2014 No Comments

A Multi-center, Double Blind, Randomized, Placebo-controlled, Parallel Group Phase IIa Study of MLR-1023 in Adult Subjects With Uncontrolled Type 2 Diabetes Clinical Trial Conditions: Type 2 Diabetes Treatments in this Clinical Trial : MLR-1023 Clinical Trial Phase: Phase 2 Eligible Clinical Trial Participant Age : Between 18 years to 70 years Can Healthy Volunteers Participate: [...]

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By: ifood.tv