By: ifood.tv

TLR9 Agonist SD-101 Ipilimumab and Radiation Therapy in Treating Patients With Low-Grade Recurrent B-cell Lymphoma

Oct 02, 2014 No Comments by

This phase I/II trial studies the side effects and best dose of ipilimumab in combination with toll-like receptor 9 (TLR9) agonist SD-101 and radiation therapy in treating patients with low-grade B-cell lymphoma that has returned. Monoclonal antibodies, such as ipilimumab, may block cancer growth in different ways by targeting certain cells. Biological therapies, such as [...]

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PCR Assay for Diagnosis of Sarcoptes Scabiei

Oct 02, 2014 No Comments by

The main objective of this study is to identify unique DNA sequences within the genome of human scabies that can be utilized to identify the parasite through PCR. Clinical Trial Conditions: Scabies Eligible Clinical Trial Participant Age : Between 0 years to 100 years Can Healthy Volunteers Participate: Yes Clinical Trial Lead Sponsor: Seton Family [...]

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Suprachoroidal Injection of Triamcinolone Acetonide in Subjects With Macular Edema Following Non-Infectious Uveitis

Oct 02, 2014 No Comments by

The study is designed to evaluate the safety and efficacy of triamcinolone acetonide, CLS-TA, in subjects with macular edema following non-infectious uveitis. A single suprachoroidal injection of one of two doses of CLS-TA will each be evaluated in subjects with macular edema following non-infectious uveitis. Clinical Trial Conditions: Uveitis, Macular Edema, Uveitis, Posterior, Uveitis, Anterior, [...]

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Cabazitaxel vs Abiraterone or Enzalutamide in Patients With Poor Prognosis Metastatic Castration-resistant Prostate Cancer

Oct 02, 2014 No Comments

The purpose of this study is to assess and compare the clinical benefit rate in patients with metastatic castrate-resistant prostate cancer and poor prognostic factors treated with cabazitaxel or novel hormonal agents (abiraterone or enzalutamide) as initial therapy, to determine which treatment is most active in this population. Clinical benefit rate is defined as PSA [...]

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FMT Versus Antimicrobials for Initial Treatment of Recurrent CDI

Oct 02, 2014 No Comments

The purpose of the study is to determine the safety and efficacy of Fecal Microbiota Transplant (FMT) for the treatment of the first recurrence of Clostridium difficile infection (CDI) as compared to standard antibiotic therapy. Patients who have tested positive for CDI within 90 days of an admission for relapse of CDI will be approached [...]

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The Efficacy of Neiguan (P6 Point) Acupressure in Patients With Gastroesophageal Reflux Disease (GERD)

Oct 02, 2014 No Comments

In recent years, there is an increasing trend in the number of patients with Gastroesophageal reflux disease (GERD). The poor response to medicine was noticed in patients with non-erosive reflux disease. According to the theory of traditional Chinese medicine, acupuncture Neiguan (P6 point) could improve the uncomfortable symptoms of the chest and upper abdomen. Therefore, [...]

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Sleep Health in Preschoolers: a Randomized Controlled Trial

Oct 02, 2014 No Comments

The SHIP study is a randomized controlled trial of an intervention for preschool children with sleep problems, in which we aim to give parents the knowledge, motivation, and skills necessary to set goals, problem-solve, and improve their child's sleep. In collecting three years of follow-up data, we will be able to determine the impact of [...]

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Phase IIIB-IV Long-Term Follow-up Study for Patients Who Participated in CAMMS03409

Oct 02, 2014 No Comments

Primary Objective: To evaluate long-term safety of alemtuzumab. Secondary Objectives: To evaluate long term efficacy of alemtuzumab. To evaluate the safety profile of patients who received other Disease Modifying Treatment's (DMT) following alemtuzumab treatment. To evaluate patient-reported Quality of Life (QoL) outcomes and health resource utilization of patients who received alemtuzumab. To evaluate as needed [...]

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RTA 408 Capsules in Patients With Friedreich’s Ataxia

Oct 02, 2014 No Comments

Friedreich's ataxia is an autosomal recessive cerebellar ataxia caused by triplet-repeat expansions. The causative mutation is a trinucleotide (GAA) repeat expansion in the first intron of the frataxin gene, leading to impaired transcription of frataxin. The pathological consequences of frataxin deficiency include a severe disruption of iron-sulfur cluster biosynthesis, mitochondrial iron overload coupled to cellular [...]

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Study of MK-3475 (Pembrolizumab) in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma After Treatment With Platinum-based and Cetuximab Therapy (MK-3475-055/KEYNOTE-055)

Oct 02, 2014 No Comments

This is a study of single-agent pembrolizumab in participants with recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) who have progressed on platinum-based and cetuximab therapy. The primary study hypothesis is that pembrolizumab will provide a clinically meaningful objective response rate (ORR). Clinical Trial Conditions: Head and Neck Squamous Cell Carcinoma (HNSCC) Treatments [...]

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Retrospective Multicenter Study to Determine 4-Year Clinical Outcomes in Subjects Previously Enrolled in the CTOT-05 Study

Oct 02, 2014 No Comments

This study is a multicenter, non-randomized, retrospective study to collect long term (4 years post-transplant) clinical outcome data on subjects previously enrolled in the CTOT-05 study (NCT00466804) to evaluate participant and graft survival. Clinical Trial Conditions: Cardiac Transplantation Eligible Clinical Trial Participant Age : Between 0 years to 100 years Can Healthy Volunteers Participate: No [...]

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MIND Score for Prolonged Mechanical Ventilation

Oct 02, 2014 No Comments

It was decided to develop a comprehensive disability score specifically designed for patients receiving prolonged mechanical ventilation (PMV); the collection of information included in the score should not impose any further intervention beyond what is routinely performed. So a new questionnaire was created (called the Multi-INdependency Dimensions (MIND) that included 3 sections (nurse, physiotherapist and [...]

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A Japanese Trial of TH-302 in Subjects With Locally Advanced Unresectable or Metastatic Soft Tissue Sarcoma

Oct 02, 2014 No Comments

This is a Phase 2, single-arm, Japanese multicenter trial to evaluate the safety, tolerability, and efficacy of TH-302 in combination with doxorubicin in subjects with locally advanced unresectable or metastatic soft tissue sarcoma (STS). Clinical Trial Conditions: Soft Tissue Sarcoma Treatments in this Clinical Trial : TH-302, Doxorubicin Clinical Trial Phase: Phase 2 Eligible Clinical [...]

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IrrSept vs. Standard of Care in Prevention of Surgical Site Infections

Oct 02, 2014 No Comments

This is a Phase IV study designed to evaluate rate of Surgical Site Infections (SSIs) when the IrriSept device is used in an open abdominal laparotomy for abdominal trauma or acute surgical abdomen. Half of the eligible subjects will be randomized to receive the IrriSept device and half of the subjects will receive the respective [...]

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Long-Term Effectiveness of Liraglutide for Treatment of Type 2 Diabetes in Daily Practice

Oct 02, 2014 No Comments

This study is conducted in Europe. The aim of this study is to investigate Long-Term Effectiveness of Liraglutide for Treatment of Type 2 Diabetes in daily Practice. Clinical Trial Conditions: Diabetes, Diabetes Mellitus, Type 2 Treatments in this Clinical Trial : Liraglutide Eligible Clinical Trial Participant Age : Between 18 years to 100 years Can [...]

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Evaluation of the esCCO Non-invasive Cardiac Output Measurement Device in Pregnancy

Oct 02, 2014 No Comments

Cardiac output (CO) is the volume of blood ejected from the heart and is a product of stroke volume (SV) vs heart rate (HR). It is closely related to Blood Pressure (BP) by the formula CO = Mean Arterial Pressure (MAP) / Systemic Vascular Resistance (SVR). Cardiac output monitoring is well established and validated for [...]

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Fully Covered SEMS Versus Partially Covered SEMS With Anti-migration System for Malignant Distal Biliary Obstruction

Oct 02, 2014 No Comments

The purpose of this study is to compare the duration of stent patency between partially covered and fully covered SEMS for palliation of malignant distal bile duct obstruction. Clinical Trial Conditions: Biliary Tract Neoplasms Treatments in this Clinical Trial : Partially covered SEMS, Fully covered SEMS Eligible Clinical Trial Participant Age : Between 19 years [...]

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Migration and Head Penetration of Vitamin-E Diffused Cemented Polyethylene Cup in Total Hip Arthroplasty

Oct 02, 2014 No Comments

In vitro, Vitamin-E diffused, highly cross-linked polyethylene (PE) have been shown to have superior wear resistance and improved mechanical properties as compared to that of standard highly cross-linked PE. There are as of yet no published studies with vitamin-E diffused PE although several trials are ongoing. All of these trials use uncemented acetabular cups intended [...]

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Safety and Immunogenicity of an Adjuvanted Trivalent Influenza Vaccine in Children 6 to <72 Months of Age in Mexico.

Oct 02, 2014 No Comments

The administration of adjuvanted Trivalent Influenza Vaccine (aTIV) has come to result in a more immunogenic and effective response compared with conventional influenza vaccines in elderly and adults. The aim of this study is to evaluate safety and immunogenicity of Novartis aTIV in children 6 to <72 months of age, Mexican population, in comparison to [...]

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Investigation of Intranasal Oxytocin on Relapse Risk in Cocaine-dependent Patients.

Oct 02, 2014 No Comments

This proposal describes a combined laboratory and clinical trial preliminary investigation to advance medication development for cocaine dependence. The main objective is to test whether intranasal Oxytocin could reduce relapse risk by reducing stress sensitivity. To measure the stress sensitivity, this study will evaluate a new stress challenge: a) Intranasal desmopressin, a vasopressin analog, will [...]

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Palbociclib Isethionate in Treating Younger Patients With Recurrent Progressive or Refractory Central Nervous System Tumors

Oct 02, 2014 No Comments

This phase I trial studies the side effects and best dose of palbociclib isethionate in treating younger patients with central nervous system tumors that have grown, come back, or not responded to treatment. Palbociclib isethionate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Clinical Trial Conditions: [...]

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Study of Low-Dose Radiation Therapy to the Whole Liver in Combination With Gemcitabine and Cisplatin in Intrahepatic Cholangiocarcinoma

Oct 02, 2014 No Comments

The overall goal of this study is to determine the safety and efficacy of combination treatment of low-dose fractionated radiation therapy with gemcitabine-cisplatin chemotherapy for locally advanced mass forming intra-hepatic cholangiocarcinoma. Clinical Trial Conditions: Intrahepatic Cholangiocarcinoma Treatments in this Clinical Trial : Gemcitabine, Cisplatin, Low dose whole liver and portal lymph node basin radiotherapy Clinical [...]

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Phase III Study Comparing Bowel Cleansing Efficacy Safety and Tolerability of NER1006 With Trisulfate Bowel Cleansing Solution Using a 2-Day Split-Dosing Regimen in Adults

Oct 02, 2014 No Comments

This study evaluates the efficacy, safety and tolerability of NER1006 with Trisulfate solution in patients requiring bowel cleansing prior to any procedure which requires a clean bowel. Half the participants will receive NER1006 and while the other half will receive Trisulfate solution. Clinical Trial Conditions: Colon Cancer, Colorectal Carcinoma Treatments in this Clinical Trial : [...]

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Combined Package of Interventions for Environmental Enteropathy

Oct 01, 2014 No Comments

Randomized, double-blind, placebo controlled trial of a combined intervention of zinc, albendazole, and multiple micronutrients in improving environmental enteropathy in Malawian children. Clinical Trial Conditions: Environmental Enteropathy Treatments in this Clinical Trial : Albendazole, Zinc, Multiple Micronutrient Supplement, Placebo Eligible Clinical Trial Participant Age : Between 1 years to 1 years Can Healthy Volunteers Participate: [...]

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Induction of Migraine Aura With Cilostazol

Oct 01, 2014 No Comments

In a double blind placebo-controlled cross-over study the effect of cilostazol on aura induction and endothelial response is tested in patient with migraine with aura. Clinical Trial Conditions: Migraine With Aura, Stroke Treatments in this Clinical Trial : Cilostazol, Placebo Eligible Clinical Trial Participant Age : Between 18 years to 50 years Can Healthy Volunteers [...]

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By: ifood.tv