Obstructive sleep apnoea is a risk factor for cerebral palsy. study hypothesis: In prospective study the investigators want to know how many cerebral palsy patients have sleep apnoea and does thrombolysis play a role in severity of osa in six months follow up. Clinical Trial Conditions: Sleep Apnoea, Cerebral Palsy Eligible Clinical Trial Participant Age [...]

The purpose of this study is to compare subcutaneous Abatacept to placebo in the treatment of psoriatic arthritis Clinical Trial Conditions: Psoriatic Arthritis Treatments in this Clinical Trial : Abatacept, Placebo matching with Abatacept Clinical Trial Phase: Phase 3 Eligible Clinical Trial Participant Age : Between 18 years to 100 years Can Healthy Volunteers Participate: [...]

This will be a randomized, controlled trial involving kidney and kidney pancreas transplant patients. There will be 2 groups and patients will be randomized to one of the two; one will receive standard of care IPC or TED stockings to help with circulation, the other group will use the geko device which is a newer [...]

The purpose of this study is the evaluation of effectiveness of paliperidone palmitate within three different group of schizophrenia patients. Clinical Trial Conditions: Schizophrenia, Chronic Akathisia Treatments in this Clinical Trial : Paliperidone palmitate Clinical Trial Phase: Phase 4 Eligible Clinical Trial Participant Age : Between 18 years to 65 years Can Healthy Volunteers Participate: [...]

Enuresis (E) or bedwetting is a common pediatric complaint, and recent research has discovered a link with obstructive sleep apnea (OSA). In children, OSA is often secondary to enlargement of their adenoids or tonsils, and is often successfully treated with a steroid solution given through the nose. The relationship between SDB and E is incompletely [...]

This post marketing observational study (PMOS) is designed to collect long-term data on the work productivity and changes in quality of life measurements with anti-Tumor Necrosis Factor therapies in patients with moderate to severe Crohn's disease whom are intolerant or/and unresponsive to conventional therapy. Clinical Trial Conditions: Crohn's Disease Eligible Clinical Trial Participant Age : [...]

We are interested in developing new and better ways of diagnosing the cause of lower respiratory tract infections including pneumonia. Currently we find the causal bug (bacteria or virus) in less than 50% of patients with pneumonia. A potential way to better find the bug responsible may include checking for bugs in the nose by [...]

As part of the long-term goal of successfully implementing tissue regeneration strategies in an individualized manner for patients with thoracic diseases including, but not limited to: cystic fibrosis, pulmonary fibrosis and pulmonary hypertension, the investigators will assess the feasibility of collecting skin biopsies from patients undergoing surgery for thoracic disease, culturing skin fibroblasts from the [...]

Background: – GATA2 deficiency is a disease caused by mutations in the GATA2 gene. It can cause different types of leukemia and other diseases. Researchers want to see if a stem cell transplant can be used to treat this condition. A stem cell transplant will give stem cells from a matching donor (related or unrelated) [...]

Restless legs syndrome (RLS) is a debilitating sleep disorder that has significant impact on quality of life, and often times can be difficult to diagnose and treat effectively. RLS is typically treated with medical therapy (including dopaminergic agents, dopamine agonists, benzodiazepines, anticonvulsants, opiates, among other therapies). Many patients are either refractory to medical therapy, have [...]

This study will assess efficacy, safety , tolerability and PK in uncomplicated adult malaria patients with acute P. falciparum infection after single dose with KAE609 at 75 mg/day Clinical Trial Conditions: Cure Rate Treatments in this Clinical Trial : KAE609 Clinical Trial Phase: Phase 2 Eligible Clinical Trial Participant Age : Between 0 years to [...]

Background: The individual's ability to sustain itself in the upright position, effectively adjusting the body's movements and reacting to external stimuli, postural control strategies represent essential activities of daily living. Diabetes mellitus type 2 (DM-2) is considered a more problem of Public Health as having complications deficit in functional performance of the lower limbs and [...]

Background: – Cord blood is blood that is taken from the umbilical cord and placenta of healthy newborns after childbirth. The cord blood collected from a baby is called a cord blood unit. Cord blood units are stored frozen in public cord blood banks. About 10,000 cord blood transplants have been performed in children and [...]

Efficacy of Dovitinib for Squamous NSCLC. Clinical Trial Conditions: Squamous NSCLC Treatments in this Clinical Trial : Dovitinib Clinical Trial Phase: Phase 2 Eligible Clinical Trial Participant Age : Between 20 years to 100 years Can Healthy Volunteers Participate: No Clinical Trial Lead Sponsor: Samsung Medical Center Detailed Clinical Trial Description: Efficacy of Dovitinib for [...]

To find the optimal dose of afatinib and nimotuzumab in patients who acquired resistance to gefitinib or erlotinib. Clinical Trial Conditions: NSCLC Treatments in this Clinical Trial : afatinib (30 or 40mg) + nimotuzumab (100 or 200mg) Eligible Clinical Trial Participant Age : Between 20 years to 100 years Can Healthy Volunteers Participate: No Clinical [...]

Primary Objective: To assess the long term safety and tolerability of SAR339658 Secondary Objective: To assess the long term efficacy of SAR339658 Clinical Trial Conditions: Ulcerative Colitis Treatments in this Clinical Trial : SAR339658 Clinical Trial Phase: Phase 2 Eligible Clinical Trial Participant Age : Between 18 years to 100 years Can Healthy Volunteers Participate: [...]

The purpose of this study is to compare the amount of coma as measured by aberrometry induced by two silicone hydrogel toric lenses in astigmatic participants. Clinical Trial Conditions: Refractive Error, Astigmatism, Myopia, Hyperopia Treatments in this Clinical Trial : Lotrafilcon B toric contact lens, Comfilcon A toric contact lens Eligible Clinical Trial Participant Age [...]

This study aims to determine if providing genomic information to veterans can help them lose weight compared to usual care. Clinical Trial Conditions: Obesity Treatments in this Clinical Trial : Personalized Genomics Eligible Clinical Trial Participant Age : Between 18 years to 100 years Can Healthy Volunteers Participate: Yes Clinical Trial Lead Sponsor: University of [...]

This current study aims to evaluate the efficacy of engagement modules in assisting patients who are candidates for renal and liver transplantation make significant lifestyle modifications. With the help of the Center for Innovation (CFI), a smartphone app (Android and iOS compatible) has been created to assist in both educating and engaging patients to develop [...]

Background: – Congenital adrenal hyperplasia (CAH) is a genetic disorder of the adrenal gland. The adrenal gland is located in the abdomen and produces small amounts of hormones such as cortisol, aldosterone, and androgen. These hormones help control blood pressure, protect the body, and maintain good health, especially during development. People with CAH do not [...]

This clinical study is being conducted to assess the safety and determine the maximum tolerated dose (MTD) of PDA-002 [human placenta-derived cells] administered into the lower leg muscles of subjects with peripheral arterial disease and diabetic foot ulcers. It will look to see if PDA-002 helps reduce some of the symptoms of PAD and/or improves [...]

This project aims to investigate how dysfunctional learning and habitization are affected by acute alcohol exposure, and whether individual differences in such alcohol effects can predict later development of Alcohol Use Disorders (AUDs). Eighty 18-year-old healthy male subjects are tested on two days in a within-subjects design with blinded administration of alcohol vs. placebo and [...]