By: ifood.tv

Raltegravir Versus Efavirenz in Naive HIV-1-infected Patients Receiving Rifampin for Active Tuberculosis

Oct 24, 2014 No Comments by

Phase III trial evaluating raltegravir as an alternative to efavirenz for antiretroviral treatment of HIV-infected patients with tuberculosis. Clinical Trial Conditions: HIV-1 Infection, Tuberculosis Treatments in this Clinical Trial : Tenofovir + lamivudine + raltegravir, Tenofovir + lamivudine + efavirenz Clinical Trial Phase: Phase 3 Eligible Clinical Trial Participant Age : Between 18 years to [...]

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CAR T Cells Targeting CD30 Positive Lymphomas (4SCAR30273)

Oct 24, 2014 No Comments by

Currently, a majority of lymphomas cannot be cured by standard chemo-radiotherapy. Cluster of differentiation antigen 30 (CD30) is expressed in many lymphoma subtypes, such as Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL). CD30 represents a very attractive target for chimeric antigen receptor (CAR)-based immune cell therapy. This study will evaluate a novel 4th [...]

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Salvage Radiotherapy Combined With Hormonotherapy in Oligometastatic Pelvic Node Relapses of Prostate Cancer

Oct 24, 2014 No Comments by

There is an increasing number of reports describing the existence of a proportion of prostate cancer patients who present with a reduced number of metastases (<5 lesions) at relapse. This oligometastatic status has also been recognized in other tumor types such as melanoma, soft tissue sarcoma, liver, lung, and breast cancer, and has influenced the [...]

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Comprehensive Genomic Analysis in Tissue and Blood Samples From Young Patients With Lung Cancer

Oct 23, 2014 No Comments

This research trial studies genomic analysis in tissue and blood samples from young patients with lung cancer. Identifying specific gene mutations (changes in deoxyribonucleic acid [DNA]) may help doctors tailor treatment to target the specific mutations and help plan effective treatment. Clinical Trial Conditions: Non-small Cell Lung Cancer, Small Cell Lung Cancer Treatments in this [...]

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Vitamin B12 Neurodevelopment and Growth in Nepal

Oct 23, 2014 No Comments

Rationale: Globally, vitamin B12 deficiency is one of the most common micronutrient deficiencies. The only relevant source of Vitamin B12 is animal-source foods. Vitamin B12 is crucial for normal cell division and is necessary for brain growth as well as for the maintenance of its normal function. Deficiency is also associated with impaired growth. In [...]

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Lung Volume Reduction Coils for Emphysema in Alpha-1 Antitrypsin Deficiency

Oct 23, 2014 No Comments

The objective of this study is to evaluate the safety and effectiveness of the RePneu Lung Volume Reduction Coil (LVRC) in patients with Alpha-1-Antitrypsin deficiency (AATD) caused emphysema. The hypothesis is that emphysema in AATD patients shows similar tissue destruction profile was well as symptoms and thus will respond favorably to LVRC treatment, demonstrating improvement [...]

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Attention Bias Modification Treatment (ABMT) for Anxiety Disorders in Youth Who do Not Respond to CBT

Oct 23, 2014 No Comments

First-line psychosocial treatments for anxiety disorders in children are largely exposure-based cognitive behavioral therapies (CBTs). Despite strong evidence supporting CBT's efficacy, for up to 50% of youth patients, symptoms of anxiety persist after a full course of treatment. What are the treatment options for these youth? Unfortunately, there is not a single empirical study in [...]

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A Study of Imatinib and Nilotinib in Patients With Chronic Myelogenous Leukemia in Chronic Phase

Oct 23, 2014 No Comments

The extension study follows the core study CAMN107ECN02, which is an open-label, two armed study. All patients enrolled in this extension study should be able to benefit from the treatment given in CAMN107ECN02 per investigator's evaluation. Therefore, in this extension study patient will continue treatment of the drug (imatinib or nilotinib) which they are taking [...]

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Analysis of Proteome and Pathophysiological Characteristics of Human Blood Cells

Oct 23, 2014 No Comments

The aim of this study is to investigate wether change in endothelial nitric oxid synthase of blood cells (erythrocytes and peripheral blood mononuclear cells (PBMC)) has an influence on development and progression of cardiovascular diseases. Clinical Trial Conditions: Red Blood Cell, Peripheral Blood Mononuclear Cell, Endothelial NO-synthase Eligible Clinical Trial Participant Age : Between 20 [...]

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Behavioral Consultation for HIV+ Older Adults Prescribed Opioids for Chronic Pain

Oct 23, 2014 No Comments

This project will develop a novel collaborative treatment, based on the primary care behavioral consultation model and behavior therapy techniques including motivational interviewing and functional assessment, in which a patient, a Behavioral Health Consultant (BHC) and a HIV primary care provider share a unified plan targeting misuse of prescribed opioid analgesics in older HIV+ adults. [...]

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Randomized Controlled and Open-label Study of Buspirone add-on Treatment in Patients With Major Depression Disorder

Oct 23, 2014 No Comments

This is a Multicenter, open lable, parallel randomized controlled clinical trial. This study aimed to evaluate the treatment onset time, efficacy and safety in patients with major depressive disorders , accompanying anxiety receiving Buspirone and Paroxetine. Clinical Trial Conditions: Major Depression Disorder Treatments in this Clinical Trial : Buspirone, Paroxetine Clinical Trial Phase: Phase 4 [...]

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Pain Perception of Children and Youth Receiving Non-sedated Botulinum Toxin-A Injections Using the Buzzy

Oct 23, 2014 No Comments

The use of Botulinum toxin injections (BoNT-A) has become a standard therapy for children and youth who suffer from stiffness of their muscles due to a neurological problem. These injections are given into each muscles which require treatment, which often means receiving multiple injections in one session. Intramuscular injections are typically painful. Treatment can be [...]

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To be Released When EU Approval Efficacy of Vortioxetine Versus Escitalopram on Cognitive Function in Patients With Inadequate Response to Current Antidepressant Treatment of Major Depressive Disorder

Oct 23, 2014 No Comments

This study aims at evaluating the effect of vortioxetine on cognitive dysfunction in major depressive disorder (MDD) patients with inadequate response to current antidepressant treatment. Clinical Trial Conditions: Major Depressive Disorder Treatments in this Clinical Trial : Vortioxetine 10-20 mg, Escitalopram 10-20 mg Clinical Trial Phase: Phase 3 Eligible Clinical Trial Participant Age : Between [...]

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Evaluate the Efficacy and Safety of Saxagliptin in Combination With Metformin IR Compared to Saxagliptin Monotherapy and to Metformin IR Monotherapy in Drug Naive Chinese Subjects With Type 2 Diabetes Who Have Inadequate Glycaemic Control

Oct 23, 2014 No Comments

A Multicenter, Randomized, Double-Blind, Active-Controlled, Phase 3 Trial to Evaluate the Efficacy and Safety of Saxagliptin in Combination with Metformin IR as Initial Therapy Compared to Saxagliptin Monotherapy and to Metformin IR Monotherapy in Subjects with Type 2 Diabetes who have Inadequate Glycaemic Control Clinical Trial Conditions: Type 2 Diabetes Mellitus Treatments in this Clinical [...]

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Is a Pre-contrast Scan Necesary to Diagnose Acute Aortic Syndrome?

Oct 23, 2014 No Comments

Acute Aortic Syndrome (AAS) is a potentially life-threatening cause of sudden, severe chest pain. There are several possible underlying causes, which cannot be distinguished from one another at the bedside. Current practice is to image this with two CT scans of the chest, one before injection of a contrast dye into the blood stream and [...]

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STARflo European Safety and Efficacy Study

Oct 23, 2014 No Comments

Prospective, Non-comparative, Multi-center clinical trial to evaluate the safety and efficacy of the STARflo Glaucoma Implant in patients with refractory open angle glaucoma. Clinical Trial Conditions: Open Angle Glaucoma Treatments in this Clinical Trial : STARflo Glaucoma Implant Eligible Clinical Trial Participant Age : Between 18 years to 100 years Can Healthy Volunteers Participate: No [...]

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Investigating the Role of the Polyol Pathway in the Central Nervous System

Oct 23, 2014 No Comments

Patients will undergo magnetic resonance spectroscopy (MRS) scanning to noninvasively measure intracerebral and plasma metabolite levels at baseline and following 2 and 4 hours of hyperglycemia. Subjects will also undergo a lumbar puncture at a separate occasion to assess cerebrospinal fluid levels of metabolites. Clinical Trial Conditions: Hyperglycemia Treatments in this Clinical Trial : Brain [...]

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Intraoperative Right Ventricular Function During Minimally Invasive and Full Sternotomy Aortic Valve Replacement

Oct 23, 2014 No Comments

This is a single-center, open-label, randomized controlled trial. Patients scheduled for aortic valve replacement (AVR) at Karolinska University Hospital in Stockholm, Sweden will be eligible. Twenty patients will be randomly assigned to either minimally invasive (10 patients) or full sternotomy AVR (10 patients). Inclusion criteria is severe aortic stenosis referred for medically indicated isolated aortic [...]

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A Protocol of the Canadian Prospective Study for Hepatocellular Carcinoma Surveillance Using Biomarkers

Oct 23, 2014 No Comments

The objective of this study is to evaluate the clinical effectiveness of biomarkers, alpha-fetoprotein (AFP), Lens culinaris agglutinin-reactive fraction of AFP (AFP-L3), and des-gamma-carboxy prothrombin (DCP), for surveillance program patients whose hepatocellular carcinoma (HCC) development may be potentially missed by ultrasound (US). This study expects to demonstrate that addition of biomarkers will increase the detection [...]

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Acceptability and Efficacy of ‘Fish Surimi Peptide’ in Under Five Children Suffering From Moderate Acute Malnutrition

Oct 23, 2014 No Comments

Protein-energy malnutrition (PEM) including moderate acute malnutrition (MAM: weight-for-height z-score <-2 to -3, or mid upper arm circumference (MUAC) 115 to < 125 mm) is a major cause of morbidity and mortality in under-5 children of developing/low-income countries. Approximately 14.6% of all under-5 mortality worldwide is attributed to MAM. Prevalence of MAM among under-5 children [...]

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Flow Mediated Dilation in Response to Black Tea

Oct 23, 2014 No Comments

Research indicate that people who regularly drink tea have a reduced risk of stroke or heart disease. In a number of studies in which people that normally do not drink showed that their blood vessels function improved when the drunk tea. The current study tests whether a specific black tea improves vessel function in non-tea [...]

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Ponatinib Hydrochloride in Treating Patients With Refractory Metastatic Cancers and Genetic Alterations

Oct 23, 2014 No Comments

This phase II trial studies how well ponatinib hydrochloride works in treating patients with cancer that has spread to other parts of the body (metastatic), has failed previous treatment (refractory), and has one of several alterations, or mutations, in its deoxyribonucleic acid (DNA) sequence. Ponatinib hydrochloride may stop the growth of cancer cells by blocking [...]

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Phase II Study of Lenalidomide/Dexamethasone With or Without Elotuzumab for Newly Diagnosed MM Patients in Japan

Oct 23, 2014 No Comments

The purpose of this study is to determine the efficacy of Lenalidomide/Dexamethasone + Elotuzumab in the subjects with newly diagnosed, previously untreated Multiple Myeloma (MM) in Japan. Clinical Trial Conditions: Multiple Myeloma Treatments in this Clinical Trial : Lenalidomide, Dexamethasone, Elotuzumab (BMS-901608) Clinical Trial Phase: Phase 2 Eligible Clinical Trial Participant Age : Between 20 [...]

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A Study to Assess the Disturbances in Calcitonin Gene in Patients With Gum Disease and Osteoporosis

Oct 23, 2014 No Comments

Osteoporosis and Periodontitis are multifactorial diseases which share common risk factors.The aim of the present study is to ellucidate polymorphisms in Calcitonin receptor gene? in patients with Osteoporosis and Periodontitis. Clinical Trial Conditions: Generalized Chronic Periodontitis, Osteoporosis Treatments in this Clinical Trial : CTR Gene Eligible Clinical Trial Participant Age : Between 35 years to [...]

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Effects of Remote Ischemic Preconditioning on Moderate PVD Patients A Pilot Randomized Control Trial

Oct 23, 2014 No Comments

Remote ischemic Preconditioning (RIPC) is a phenomena first observed in cardio-thoracic patients in which exposing the limbs for periods of short intermittent ischemia produces protective effect on heart muscle. The concept was applied to many other parts of the body and the results are positive so far. No human trials on this concept has been [...]

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By: ifood.tv