By: ifood.tv

Partnership for Research on Ebola Vaccines in Liberia (PREVAIL)

Jan 26, 2015 No Comments by

Ebola virus disease (EVD) in West Africa is spreading rapidly, and there is a critical need for a vaccine to prevent EVD. There are two candidate Ebola virus vaccines, the chimpanzee adenovirus 3 (ChAd3-EBO Z)-based vaccine and the Vesicular Stomatitis virus (VSVdeltaG-ZEBOV)-based vaccine. This study will evaluate both of these vaccines in a randomized, double-blind, [...]

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Calcineurin Inhibitor-Free Interventions for Prevention of Graft-versus-Host Disease (BMT CTN 1301)

Jan 26, 2015 No Comments by

The study is designed as a three arm randomized Phase III, multicenter trial comparing two calcineurin inhibitor (CNI)-free strategies for Graft-versus-Host Disease (GVHD) prophylaxis to standard tacrolimus and methotrexate (Tac/Mtx) in patients with hematologic malignancies undergoing myeloablative conditioning hematopoietic stem cell transplantation. Clinical Trial Conditions: Acute Leukemia, Myelodysplasia Treatments in this Clinical Trial : Unmanipulated [...]

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Olaparib and Cediranib Maleate in Treating Patients With Recurrent Ovarian Peritoneal or Fallopian Tube Cancer

Jan 26, 2015 No Comments by

This phase II trial studies how well olaparib and cediranib maleate work in treating patients with ovarian, peritoneal, or fallopian tube cancer that has come back (recurrent). Olaparib and cediranib maleate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Clinical Trial Conditions: Fallopian Tube Endometrioid Adenocarcinoma, [...]

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Empowering Immigrants in the Greater Boston Area to Connect to HBV Care

Jan 21, 2015 No Comments

This Study will attempt to provide information / linkage to HBV care for persons at risk in the Greater Boston area. Clinical Trial Conditions: Hepatitis Eligible Clinical Trial Participant Age : Between 18 years to 100 years Can Healthy Volunteers Participate: Yes Clinical Trial Lead Sponsor: Massachusetts General Hospital Detailed Clinical Trial Description: This Study [...]

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Sustained Acoustic Medicine for Tendon Healing

Jan 16, 2015 No Comments

The purpose of this study is to measure the effectiveness of a wearable therapeutic ultrasound device in patients with tendinopathies of the elbow (medial or lateral), Achilless tendon, or patellar tendon. The ability of the device to reduce pain, increase activity, increase strength, and improve quality of life will be evaluated. While the use of [...]

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Patient NAVIgation to Reduce Readmissions Among Black Men With Heart Failure

Jan 16, 2015 No Comments

The investigators are asking subjects to take part in the Patient NAVIgation to Reduce Readmissions among Black Men with Heart Failure (NAVI-HF) research study. This research study will test how well trained laypeople working as patient navigators will help patients recently hospitalized for heart failure avoid future hospitalizations. NAVI-HF is a new program sponsored by [...]

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A Study of Lebrikizumab in Patients With Persistent Moderate to Severe Atopic Dermatitis

Jan 16, 2015 No Comments

This randomized, double-blind, placebo-controlled study will evaluate the safety and efficacy of lebrikizumab administered subcutaneously (SC) in adult patients with moderate to severe atopic dermatitis (AD) who are inadequately controlled by topical corticosteroids (TCS). The study includes a screening visit, a 12-week blinded treatment period, and an 8-week safety follow-up period. During the treatment period, [...]

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Pilot Study of Effects of Cold Vests on Cardiovascular Risk Markers

Jan 16, 2015 No Comments

Randomized trial of supplying a cold vest as compared with controls (no cold vest) on cardiovascular risk factors such as blood lipids, insulin, blood pressure and body weight and also on basal metabolic rate. Recruitment of 100 participants and 70 are randomized to being given a vest which they can use to increase basal metabolic [...]

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SANDPIPER Study: A Study Of Taselisib + Fulvestrant Versus Placebo + Fulvestrant In Patients With Advanced or Metastatic Breast Cancer Who Have Disease Recurrence or Progression During or After Aromatase Inhibitor Therapy

Jan 16, 2015 No Comments

This international, multicenter, randomized, double-blinded, placebo-controlled study is designed to compare the efficacy and safety of taselisib + fulvestrant with that of placebo + fulvestrant in postmenopausal women with estrogen receptor (ER)-positive, human epidermal growth factor receptor-2 (HER2)-negative, PIK3CA-mutant, unresectable, locally advanced or metastatic breast cancer after recurrence or progression during or after an aromatase [...]

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Effect of Oral Pregabalin on Hyperalgesia and Post-operative Pain in Patients Undergoing Nephrectomy Surgery: Sex Differential Study

Jan 16, 2015 No Comments

Hyperalgesia is known to be caused by the excitatory amino acid through NMDA receptor. GABA, an inhibitory amino acid, alters the opioid receptor sensitivity against pain resulting hyperalgesia. If the GABA level can be maintained at certain level, the progression into hyperalgesia can be averted. GABA related drugs are known to decrease the postoperative opioid [...]

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Effect of Oral Pregabalin on Hyperalgesia and Post-operative Pain in Patients Undergoing Nephrectomy Surgery: Sex Differential Study

Jan 16, 2015 No Comments

Hyperalgesia is known to be caused by the excitatory amino acid through NMDA receptor. GABA, an inhibitory amino acid, alters the opioid receptor sensitivity against pain resulting hyperalgesia. If the GABA level can be maintained at certain level, the progression into hyperalgesia can be averted. GABA related drugs are known to decrease the postoperative opioid [...]

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Endocuff-assisted vs. Standard Colonoscopy

Jan 16, 2015 No Comments

The aim of this study is to evaluate Endocuff- assisted colonoscopy in terms of its possible additive contribution in the detection of important lesions, namely polyps and cancers, compared to standard colonoscopy, in a series of patients undergoing back-to-back screening or surveillance colonoscopies in a randomized fashion. Moreover, we aim to assess possible changes regarding [...]

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Endocuff-assisted vs. Standard Colonoscopy

Jan 16, 2015 No Comments

The aim of this study is to evaluate Endocuff- assisted colonoscopy in terms of its possible additive contribution in the detection of important lesions, namely polyps and cancers, compared to standard colonoscopy, in a series of patients undergoing back-to-back screening or surveillance colonoscopies in a randomized fashion. Moreover, we aim to assess possible changes regarding [...]

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A Study to Measure Baricitinib (LY3009104) Absorption in Healthy Participants

Jan 16, 2015 No Comments

The pupose of this study is to compare how much baricitinib (study drug) gets into the blood stream when it is given as a single dose (in tablet form) and as an intravenous infusion (injection given directly into a vein via a small needle). Each participant in the study will make four visits to the [...]

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Pill Study Hyperthermia Device (Heckel HT 3000): Monitoring Core Body Temperature Using Wireless Technology

Jan 16, 2015 No Comments

The primary objective of the proposed study is to determine the use of a wireless method to monitor and record core body temperature during a Whole Body Hyperthermia treatment, compared to an indwelling rectal thermometer. This protocol is intended to study the differences between a rectal temperature probe and an approved wireless and indigestible thermometer [...]

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Optimizing Technology-Delivered Interventions for Smoking in Pregnancy: The Mommy Check-Up Study.

Jan 16, 2015 No Comments

Tobacco smoking in pregnancy remains one of the most important and preventable cause of adverse pregnancy outcomes. Data from National Survey of Drug Use and Health (NSDUH) suggests, that the annual average rates of current cigarette use among women aged 15 to 44 who were not pregnant decreased from 30.7 percent in 2002-2003 to 24.0 [...]

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Phase II Trial of SBRT + or – IMRT in Treatment of Patients With Clinically Confined Prostate Adenocarcinoma

Jan 16, 2015 No Comments

Patients with locally confined prostate adenocarcinoma (clinical stage T1c – T2bN0M0, Gleason score 7, PSA 20 ng/ml) are assigned to one of two treatment arms. Low risk patients (T1c-T2a and PSA <10 ng/ml and Gleason Score 6 or less) will receive 5 fractions of 8.0 Gy for a total of 40 Gy. Intermediate risk patients [...]

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Trajectory Changes of Coronary Sinus Lead Tip and Cardiac Resynchronization Therapy Outcome

Jan 16, 2015 No Comments

In chronic systolic heart failure patients submitted to cardiac resynchronization therapy, the study aims at assessing whether geometric variations in coronary sinus lead tip trajectory throughout the cardiac cycle acutely induced by biventricular pacing, are predictive of the volumetric and clinical response to the treatment at six-month follow-up. Clinical Trial Conditions: Heart Failure, Left-Sided Heart [...]

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Evaluating Pulmonary Arterial Hypertension in Patients With Systemic Sclerosis

Jan 16, 2015 No Comments

Doppler signals can be recorded from the lung parenchyma by means of a pulsed Doppler ultrasound system incorporating a special signal processing package- the Transthoracic Parametric Doppler (TPD) (Echosense Ltd., Haifa, Israel). Systemic sclerosis patients often develop pulmonary vascular disease leading to pulmonary hypertension. The TPD system may provide important insight into pulmonary blood vessels [...]

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A Study of Cediranib and Olaparib at the Time Ovarian Cancer Worsens on Olaparib

Jan 16, 2015 No Comments

This is a phase 2 study (the second phase in testing a new drug or drug combination) to see how useful adding investigational drug cediranib to olaparib after disease progression on olaparib alone in patients with ovarian cancer. Clinical Trial Conditions: Ovarian Cancer Treatments in this Clinical Trial : Olaparib, Cediranib Clinical Trial Phase: Phase [...]

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An Online Enhanced Education Tool for Young Women Newly Diagnosed With Breast Cancer

Jan 16, 2015 No Comments

This project proposes to develop and test an internet resource – a supported self-management website – that will guide younger women to relevant knowledge and resources, and provide tools that will help YWBC become more skilled and confident in coping with the many challenges of breast cancer. The study will be conducted in collaboration with [...]

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Effects of Fruit Extracts on Glycaemia: The GLU-FRU Study

Jan 16, 2015 No Comments

Raised blood glucose levels can lead to adverse modifications to functional proteins within the body and eventually lead to the development of type 2 diabetes. Fruit polyphenols may help to control glycaemia following a carbohydrate meal or beverage. The aim of this study is to investigate the effects of blackcurrant (BC) and apple (A) extracts [...]

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Effects of Bile Acids on GLP-1 Secretion After Roux-en-Y Gastric Bypass

Jan 16, 2015 No Comments

The purpose of this study is to examine the effects of bile acids on GLP-1 secretion after Roux-en-Y gastric bypass. Clinical Trial Conditions: Severe Obesity Treatments in this Clinical Trial : Water, Ursodeoxycholic Acid, Chenodeoxycholic Acid Clinical Trial Phase: Phase 4 Eligible Clinical Trial Participant Age : Between 0 years to 100 years Can Healthy [...]

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Pain Map DK: a Prospective Cohort Study of Pain Treatment in 500 Hip Arthroplasty Patients at Different Danish Hospitals

Jan 16, 2015 No Comments

This is a prospective observational cohorte study. The aim is to investigate actual pain treatment and outcomes in a large population of total hip arthroplasty patients at 5 different hospitals in Denmark. Clinical Trial Conditions: Postoperative Pain Treatments in this Clinical Trial : Pain treatment Eligible Clinical Trial Participant Age : Between 18 years to [...]

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Breast Tumor Oxygenation During Exercise

Jan 16, 2015 No Comments

In the field of cancer treatment, it is generally accepted that the enhancement of oxygen delivery to tumors can augment the effect of anti-cancer therapies. In the case of chemotherapy, this enhancement might lead to a larger amount of a given dose of treatment reaching the tumor and having an effect. Clinical Trial Conditions: Breast [...]

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By: ifood.tv