By: ifood.tv

Sodium Fluoride Imaging of Abdominal Aortic Aneurysms

Aug 29, 2014 No Comments by

The purpose of this study is to determine whether Sodium Fluoride imaging (using Positron Emission Tomography-Computed Tomography – PET-CT) is able to help predict the rate of abdominal aortic aneurysm expansion. Clinical Trial Conditions: Abdominal Aortic Aneurysm Treatments in this Clinical Trial : 18F-NaF PET-CT Eligible Clinical Trial Participant Age : Between 50 years to [...]

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Perioperative Anticoagulant Use for Surgery Evaluation Study

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The aim of the Perioperative Anticoagulant Use for Surgery Evaluation (PAUSE) Study, is to establish a safe, standardized protocol for the perioperative management of patients with atrial fibrillation (AF) who are receiving a novel oral anticoagulant (NOAC) drug, either dabigatran, rivaroxaban or apixaban, and require an elective surgery/procedure. Clinical Trial Conditions: Atrial Fibrillation Eligible Clinical [...]

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Phase 1 Single Ascending Dose Study to Evaluate Safety Tolerability and Pharmacokinetics of KBP-5074

Aug 29, 2014 No Comments by

This single ascending dose (SAD) study in healthy subjects will evaluate the safety, tolerability and pharmacokinetics of KBP-5074. PK/PD (plasma aldosterone, serum potassium and urine albumin levels) relationships will be explored to support the selection of dosing regimens of KBP-5074 that are suitable for the Phase 2 dose-finding study to evaluate the efficacy, safety and [...]

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Healthcare Text Messaging to Improve Diet Physical Activity and Weight Loss in a Pediatric Lipid Clinic

Aug 29, 2014 No Comments

The purpose of this study is to determine if health-related text messages sent from healthcare providers to overweight and obese adolescents enrolled at a pediatric lipid clinic will result in increased adherence to their nutrition and physical activity goals and improve their weight loss. The study will also assess if the volume of texts per [...]

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Molecular Features and Pathways in Predicting Resistance in Patients With Metastatic Hormone-Resistant Prostate Cancer Receiving Enzalutamide

Aug 29, 2014 No Comments

This research trial studies molecular features and pathways in predicting resistance in patients with hormone-resistant prostate cancer that has spread to another place in the body and are receiving enzalutamide. Studying samples of blood and tissue in the laboratory from patients receiving enzalutamide may help doctors learn more about molecular features and pathways that cause [...]

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Efficacy and Safety of Prucalopride in Combination With Polyethylene Glycol or Lactulose in Women With Chronic Constipation

Aug 29, 2014 No Comments

The purpose of this study is to evaluate the efficacy of prucalopride 2 mg, given orally once daily for 12 weeks, in combination with PEG or lactulose, in treatment of women with Chronic Constipation (CC) in whom laxatives fail to provide adequate relief, as measured by the percentage of subjects with a weekly average increase [...]

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Academic Achievement in Children With Asthma

Aug 29, 2014 No Comments

Background: Asthma is the most common chronic disease of childhood with a prevalence that is 1.6 times greater in African American (AA) children than in Non-Hispanic White children.1 Nationally, 700,000 children are seen for asthma in Emergency Departments (ED) every year, 1% of which are seen at Children's National Health System (CN) in Washington, DC. [...]

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Miracle Mouthwash Plus Hydrocortisone vs Prednisolone Mouth Rinse for Mouth Sores Caused by Everolimus

Aug 29, 2014 No Comments

This is a randomized Phase 2 study to evaluate two different steroid-based mouth rinses (Miracle Mouth Wash plus hydrocortisone versus prednisolone oral rinse) for the prevention or treatment of everolimus-associated stomatitis (mouth sores) in postmenopausal patients undergoing treatment with an aromatase inhibitor plus everolimus. An exploratory analysis will also evaluate patient response to next anti-cancer [...]

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Safety and Cardiovascular Efficacy of Hydralazine and Isosorbide Dinitrate in Dialysis-Dependent ESRD

Aug 29, 2014 No Comments

This study is a pilot study designed to compare the safety and cardiovascular effects of 26 weeks of combination hydralazine/isorsorbide dinitrate therapy with amlodipine therapy in patients receiving chronic hemodialysis. The investigators hypothesize that treatment of chronic hemodialysis (ESRD) patients with a combination of hydralazine/isosorbide dinitrate compared with amlopdipine is safe and that it will [...]

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Alcohol Screening Brief Intervention and Referral to Treatment in a Military Treatment Facility

Aug 29, 2014 No Comments

An alcohol Screening, Brief Intervention and Referral to Treatment (SBIRT) approach will be adapted for use in a large military hospital setting, and then pilot tested in a military emergency department (ED) to assess its potential for effectiveness and for further testing in a large-scale trial. SBIRT is an "opportunistic" approach whereby all adult patients [...]

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Safety and Efficacy of Donafenib in Patients With Advanced Hepatocellular Carcinoma

Aug 29, 2014 No Comments

This phase IB study of donafenib, an oral multikinase inhibitor that targets Raf kinase and receptor tyrosine kinases, is to assess toxicity,efficacy and pharmacokinetics in patients wiht advanced hepatocellular carcinoma (HCC) . Clinical Trial Conditions: HCC Treatments in this Clinical Trial : Donafenib(200mg), Donafenib(300mg) Eligible Clinical Trial Participant Age : Between 18 years to 70 [...]

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Efficacy of Coordinated Insulin Boluses in Type 1 Diabetic Patients

Aug 29, 2014 No Comments

A recent study suggests that, in Type 1 Diabetes (T1D) patients treated by insulin pumps, a better coordination of meal boluses and post prandial basal rate could reduce the importance of postprandial hyperglycaemias without increasing the risk of delayed hypoglycaemias. The aim of the investigators study is to assess if these results are confirmed in [...]

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Safety And Efficacy Study Of Bosutinib In Patients With Philadelphia Chromosome Positive Chronic Myeloid Leukemia Previously Treated With One Or More Tyrosine Kinase Inhibitors

Aug 29, 2014 No Comments

The purpose of this study is to fulfill the post-authorization commitment made by Pfizer to the European Medicines Agency in providing additional safety and efficacy data in approximately 150 Philadelphia Chromosome Positive Chronic Myeloid Leukemia patients with high unmet medical need, including 75 Chronic Phase, Accelerated Phase or Blast Phase patients in the fourth or [...]

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Selective Inhibitor of Nuclear Export (SINE) Selinexor (KPT-330) in Patients With Myelodysplastic Syndromes

Aug 29, 2014 No Comments

The purpose of this study is to see if selinexor will improve the blood counts and bone marrow function in people with your type of MDS. Clinical Trial Conditions: Myelodysplastic Syndromes Treatments in this Clinical Trial : Selinexor (KPT-330) Clinical Trial Phase: Phase 2 Eligible Clinical Trial Participant Age : Between 18 years to 100 [...]

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Phase 2 Study of Standard Chemotherapy With Trastuzumab Plus or Minus Pertuzumab for Pre-treated Metastatic Breast Cancer

Aug 29, 2014 No Comments

This randomized phase 2 study will seek to determine the effectiveness of chemotherapy (physician's choice of vinorelbine, taxane [paclitaxel, docetaxel or nab paclitaxel] or capecitabine) plus trastuzumab vs chemotherapy (physician's choice) plus trastuzumab plus pertuzumab in women with HER2-overexpressing metastatic breast (MBC) that has been previously treated with ado-trastuzumab emtansine (T-DM1) in the metastatic setting. [...]

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Very-Low Nicotine Cigarettes and Non-Daily Smokers

Aug 29, 2014 No Comments

The purpose of this research study is to investigate the impact of different nicotine levels in cigarettes among non-daily smokers. This research may help inform the Food and Drug Administration (FDA) on how best to regulate tobacco products in the future, with the goal of improving public health. Clinical Trial Conditions: Smoking Treatments in this [...]

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Levetiractam Treatment of Neonatal Seizures: Safety and Efficacy Phase II Study

Aug 29, 2014 No Comments

LEVNEONAT is a multicentre French clinical trials with the aim to develop new treatment strategies for the treatment of neonatal seizures using Levetiracetam. The purpose of this study is to determine the correct dosing, safety and efficacy for intravenous levetiracetam in term new born babies with seizures. This new anticonvulsivant drug is a promising treatment [...]

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Hypoglycemia in Hospitalized Patients

Aug 29, 2014 No Comments

Patients with diabetes who develop low blood sugars (hypoglycemia) in the hospital are at risk for losing the ability to develop symptoms that warn them that they are having a low blood sugar. There is almost no available information investigating how the inability to feel symptoms of a low blood sugar contributes to the risk [...]

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Study to Evaluate Real-world Pharmacoeconomics of Crizotinib in NSCLC Patients

Aug 29, 2014 No Comments

This is a phase IV multicenter trial to evaluate the pharmacoeconomic (PE) impact of crizotinib and its companion diagnostic test used in a real-life setting in advanced ALK-positive non-small cell lung cancer (NSCLC) patients. NSCLC represent 80% of all new cases of lung cancer. One molecular subtype of NSCLC is the ALK-positive subtype. The anaplastic [...]

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Utility of CrocsRx Clog as a Diabetic House Shoe: a Pilot Study

Aug 29, 2014 No Comments

Foot complications are a common and costly problem for subjects with diabetes. Although Medicare provides a pair of diabetic shoes yearly for subjects with diabetes, many do not wear their diabetic shoes in and around their house. Instead, subjects may wear shoes, such as flip flops or slippers, that provide little to no protection against [...]

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The Health-Promoting Role of Pears in Men and Women With Metabolic Syndrome

Aug 29, 2014 No Comments

The hypothesis of this study is that the daily consumption of 2 medium-sized pears for twelve weeks will improve blood pressure, lipid profiles, glycemic control and insulin resistance, inflammatory and oxidative status in men and women with metabolic syndrome. 50 men and women between the ages of 45 and 65 who have three of the [...]

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The Effect of Citric Flavonoid on Endothelial Function

Aug 29, 2014 No Comments

This randomized, double-blind, placebo-controlled, parallel study aims to determine the 6-week and acute effects of daily administration of a citrus flavonoid on cardiovascular and intestinal health as assessed by investigation of endothelial function, blood pressure and heart rate, glucose/insulin metabolism, lipid profile and gut barrier function in overweigh subjects. Futhermore we aim to relate the [...]

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Study of Pomalidomide Combined With Modified DA-EPOCH and Rituximab in KSHV-Associated Lymphomas

Aug 29, 2014 No Comments

Background: – The chemotherapy combination DA-EPOCH-RP includes the drugs etoposide (E), prednisone (P), vincristine (O), cyclophosphamide (C), doxorubicin (H), rituximab (R), and pomalidomide (P). Researchers want to see if including pomalidomide will help people with two rare lymphomas. Objectives: – To study the safety and efficacy of the chemotherapy drugs DA-EPOCH-RP. Eligibility: – Adults at [...]

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Study To Evaluate The Safety Tolerability And Pharmacokinetics Of Single Doses Of PF-04958242 In Healthy Volunteers

Aug 29, 2014 No Comments

This study aims to assess the safety, tolerability, and pharmacokinetics of PF-04958242 at a number of single ascending doses in healthy volunteers Clinical Trial Conditions: Healthy Treatments in this Clinical Trial : PF-04958242, Placebo Clinical Trial Phase: Phase 1 Eligible Clinical Trial Participant Age : Between 18 years to 55 years Can Healthy Volunteers Participate: [...]

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A Study of DCC-2701 in Participants With Advanced Solid Tumors

Aug 29, 2014 No Comments

The main purpose of this study is to investigate the safety of the investigational drug DCC-2701 and whether it will work to help people who have advanced solid tumors or cancer that has spread to other parts of the body. Clinical Trial Conditions: Locally Advanced Tumors, Metastatic Solid Tumors Treatments in this Clinical Trial : [...]

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By: ifood.tv